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Description: HIV-1 and HIV-2 protease inhibitor
Alternative Names: ABT-538,A-84538,Abbot 84538
Chemical Name: 5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoate
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Ritonavir

Ritonavir is a HIV-1 and HIV-2 protease inhibitor (EC50 values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable. When used in combination with lopinavir, improves outcome in an animal model of MERS-CoV infection.

Compound Libraries for Ritonavir

Ritonavir is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ritonavir

M. Wt 720.94
Formula C37H48N6O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 155213-67-5
PubChem ID 392622
Smiles O[C@@H](C[C@@H](NC([C@H](C(C)C)NC(N(C)CC1=CSC(C(C)C)=N1)=O)=O)CC2=CC=CC=C2)[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ritonavir

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.42 20 with gentle warming
ethanol 7.21 10

Preparing Stock Solutions for Ritonavir

The following data is based on the product molecular weight 720.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.94 mL 34.68 mL 69.35 mL
1 mM 1.39 mL 6.94 mL 13.87 mL
2 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.14 mL 0.69 mL 1.39 mL

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References for Ritonavir

References are publications that support the biological activity of the product.

Kempf et al (1995) ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.U.S.A. 92 2484 PMID: 7708670

Kempf et al (1998) Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J.Med.Chem. 41 602 PMID: 9484509

Zeldin et al (2004) Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. J.Antimicrob.Chemother. 53 4 PMID: 14657084

Chan et al (2015) Treatment with Lopinavir/Ritonavir or Interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset. J.Infect.Dis. 12 1904 PMID: 26198719

If you know of a relevant reference for Ritonavir, please let us know.

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1 Citation for Ritonavir

Citations are publications that use Tocris products. Selected citations for Ritonavir include:

Matthew B et al (2021) The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia. Sci Transl Med 13 PMID: 34408078

Do you know of a great paper that uses Ritonavir from Tocris? Please let us know.

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