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Cat.No. 5856 - Ritonavir | C37H48N6O5S2 | CAS No. 155213-67-5
Description: HIV-1 and HIV-2 protease inhibitor
Alternative Names: ABT-538, A-84538, Abbot 84538
Chemical Name: 5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoate
Purity: ≥98% (HPLC)

Biological Activity

HIV-1 and HIV-2 protease inhibitor (EC50 values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable.

Technical Data

M. Wt 720.94
Formula C37H48N6O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 155213-67-5
PubChem ID 392622
Smiles O[C@@H](C[C@@H](NC([C@H](C(C)C)NC(N(C)CC1=CSC(C(C)C)=N1)=O)=O)CC2=CC=CC=C2)[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.42 20 with gentle warming
ethanol 7.21 10

Preparing Stock Solutions

The following data is based on the product molecular weight 720.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.94 mL 34.68 mL 69.35 mL
1 mM 1.39 mL 6.94 mL 13.87 mL
2 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.14 mL 0.69 mL 1.39 mL

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References are publications that support the biological activity of the product.

Kempf et al (1995) ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.U.S.A. 92 2484 PMID: 7708670

Kempf et al (1998) Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J.Med.Chem. 41 602 PMID: 9484509

Zeldin et al (2004) Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. J.Antimicrob.Chemother. 53 4 PMID: 14657084

If you know of a relevant reference for Ritonavir, please let us know.

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