Lofepramine

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Cat.No. 2545 - Lofepramine | C26H27N2OCl | CAS No. 23047-25-8
Description: 5-HT and noradrenalin re-uptake inhibitor (SNRI)
Alternative Names: Lopramine, Leo 640
Chemical Name: 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo.

Technical Data

M. Wt 418.97
Formula C26H27N2OCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 23047-25-8
PubChem ID 3947
InChI Key SAPNXPWPAUFAJU-UHFFFAOYSA-N
Smiles CN(CCCN1C2=CC=CC=C2CCC2=CC=CC=C12)CC(=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.42 75
ethanol 4.19 10

Preparing Stock Solutions

The following data is based on the product molecular weight 418.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.93 mL 23.87 mL
5 mM 0.48 mL 2.39 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Leonard (1987) A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. Int.Clin.Psychopharmacol. 2 281 PMID: 2891742

Badawy et al (1991) The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat Biochem.Pharmacol. 42 921 PMID: 1867646

Kelly and Leonard (1999) An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur.Neuropsychopharmacol. 9 101 PMID: 10082234


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Citations for Lofepramine

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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