Serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 418.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.39 mL||11.93 mL||23.87 mL|
|5 mM||0.48 mL||2.39 mL||4.77 mL|
|10 mM||0.24 mL||1.19 mL||2.39 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the products' biological activity.
Leonard (1987) A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. Int.Clin.Psychopharmacol. 2 281 PMID: 2891742
Badawy et al (1991) The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat Biochem.Pharmacol. 42 921 PMID: 1867646
Kelly and Leonard (1999) An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur.Neuropsychopharmacol. 9 101 PMID: 10082234
If you know of a relevant reference for Lofepramine, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Lofepramine, supplier, 5-HT, noradrenalin, noradrenaline, reuptake, inhibitors, inhibits, SNRI, Noradrenalin, Transporter, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, Leo640, Lopramine, Leo, 640, 5-HT, Transporters, Adrenergic, Transporters, 5-HT, Transporters, Tocris Bioscience
Citations for Lofepramine
Citations are publications that use Tocris products.
Currently there are no citations for Lofepramine. Do you know of a great paper that uses Lofepramine from Tocris? If so please let us know.
Reviews for Lofepramine
There are currently no reviews for this product. Be the first to review Lofepramine and earn rewards!
Have you used Lofepramine?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.