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Description: 5-HT and NA reuptake inhibitor (SNRI)
Alternative Names: Lopramine, Leo 640
Chemical Name: 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Lofepramine

Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo.

Technical Data for Lofepramine

M. Wt 418.97
Formula C26H27N2OCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 23047-25-8
PubChem ID 3947
Smiles CN(CCCN1C2=CC=CC=C2CCC2=CC=CC=C12)CC(=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lofepramine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.42 75
ethanol 4.19 10

Preparing Stock Solutions for Lofepramine

The following data is based on the product molecular weight 418.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.18 mL 15.91 mL 31.82 mL
3.75 mM 0.64 mL 3.18 mL 6.36 mL
7.5 mM 0.32 mL 1.59 mL 3.18 mL
37.5 mM 0.06 mL 0.32 mL 0.64 mL

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References for Lofepramine

References are publications that support the biological activity of the product.

Leonard (1987) A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. Int.Clin.Psychopharmacol. 2 281 PMID: 2891742

Badawy et al (1991) The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat Biochem.Pharmacol. 42 921 PMID: 1867646

Kelly and Leonard (1999) An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur.Neuropsychopharmacol. 9 101 PMID: 10082234

If you know of a relevant reference for Lofepramine, please let us know.

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Citations for Lofepramine

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.