LIMKi 3

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Cat.No. 4745 - LIMKi 3 | CAS No. 1338247-35-0
Description: Potent LIM kinase inhibitor; antitumor
Alternative Names: BMS 5
Chemical Name: N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.

Compound Libraries

LIMKi 3 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 431.29
Formula C17H14Cl2F2N4OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1338247-35-0
PubChem ID 56965901
InChI Key IVUGBSGLHRJSSP-UHFFFAOYSA-N
Smiles FC(F)C1=NN(C2=C(Cl)C=CC=C2Cl)C(C3=CN=C(NC(C(C)C)=O)S3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 431.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.19 mL
5 mM 0.46 mL 2.32 mL 4.64 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ross-Macdonald et al (2008) Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol.Cancer Ther. 7 3490 PMID: 19001433

Scott et al (2010) LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J.Cell Biol. 191 169 PMID: 20876278

Sparrow et al (2012) The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination. J.Neurosci. 32 5284 PMID: 22496574


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Citations for LIMKi 3

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Literature in this Area

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