LH 846

Pricing Availability Delivery Time Qty
Cat.No. 4896 - LH 846 | C16H13ClN2OS | CAS No. 639052-78-1
Description: Selective casein kinase 1δ inhibitor
Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.

Compound Libraries

LH 846 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 316.81
Formula C16H13ClN2OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 639052-78-1
PubChem ID 851474
InChI Key DYHAMRNAHTWYKY-UHFFFAOYSA-N
Smiles O=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 316.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.78 mL 31.56 mL
5 mM 0.63 mL 3.16 mL 6.31 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lee et al (2011) A small molecule modulates circadian rhythms through phosphorylation of the period protein. Agnew Chem.Int.Ed.Engl. 50 10608 PMID: 21954091


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View all Casein Kinase 1 Inhibitors

Keywords: LH 846, LH 846 supplier, LH846, casein, kinase, I, CK1, CK1d, CK1delta, CK1δ, selective, inhibitors, inhibits, circadian, rhythm, clock, Casein, Kinase, 1, 4896, Tocris Bioscience

3 Citations for LH 846

Citations are publications that use Tocris products. Selected citations for LH 846 include:

Greer et al (2017) Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. PLoS One 12 e0170903 PMID: 28125685

Causton et al (2015) Metabolic cycles in yeast share features conserved among circadian rhythms. Curr.Biol. 25 1056 PMID: 25866393

Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242 PMID: 24424021


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Reviews for LH 846

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