LH 846

Pricing Availability Delivery Time Qty
Cat.No. 4896 - LH 846 | C16H13ClN2OS | CAS No. 639052-78-1
Description: Selective casein kinase 1δ inhibitor
Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.

Compound Libraries

LH 846 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 316.81
Formula C16H13ClN2OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 639052-78-1
PubChem ID 851474
InChI Key DYHAMRNAHTWYKY-UHFFFAOYSA-N
Smiles O=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.68 100
ethanol 1.58 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 316.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.78 mL 31.56 mL
5 mM 0.63 mL 3.16 mL 6.31 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lee et al (2011) A small molecule modulates circadian rhythms through phosphorylation of the period protein. Agnew Chem.Int.Ed.Engl. 50 10608 PMID: 21954091


If you know of a relevant reference for LH 846, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Casein Kinase 1 Inhibitors

Keywords: LH 846, supplier, LH846, casein, kinase, I, CK1, CK1d, CK1delta, CK1δ, selective, inhibitors, inhibits, circadian, rhythm, clock, Casein, Kinase, 1, Tocris Bioscience

2 Citations for LH 846

Citations are publications that use Tocris products. Selected citations for LH 846 include:

Causton et al (2015) Metabolic cycles in yeast share features conserved among circadian rhythms. Curr.Biol. 25 1056 PMID: 25866393

Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242 PMID: 24424021


Do you know of a great paper that uses LH 846 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Pathways for LH 846

Protocols

TODO: Add Protocols