Reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.
(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 10 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 475.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.11 mL||10.53 mL||21.05 mL|
|5 mM||0.42 mL||2.11 mL||4.21 mL|
|10 mM||0.21 mL||1.05 mL||2.11 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150 PMID: 1877091
Sarin et al (1994) Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J.Immunol. 153 862 PMID: 8021517
Wang (1990) Developing selective inhibitors of calpain. TiPS 11 139 PMID: 2185586
If you know of a relevant reference for Leupeptin hemisulfate, please let us know.
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Keywords: inhibitors inhibits trypsin-like cysteine proteases Proteases Proteinases Other Proteases
1 Citation for Leupeptin hemisulfate
Citations are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:
Haller et al (2015) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. J Pharmacol Exp Ther 10 2269 PMID: 25629932
Do you know of a great paper that uses Leupeptin hemisulfate from Tocris? If so please let us know.
Literature in this Area
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