Leupeptin hemisulfate

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Cat.No. 1167 - Leupeptin hemisulfate | Ac-Leu-Leu-Arginal | CAS No. 103476-89-7
Description: Inhibits trypsin-like/cysteine proteases
Citations (1)

Biological Activity

Reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.

Technical Data

M. Wt 475.04
Formula C20H38N6O4.½H2SO4
Sequence LLR

(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)

Storage Desiccate at -20°C
CAS Number 103476-89-7
PubChem ID 2733491
Smiles OS(O)(=O)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 475.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.53 mL 21.05 mL
5 mM 0.42 mL 2.11 mL 4.21 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150 PMID: 1877091

Sarin et al (1994) Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J.Immunol. 153 862 PMID: 8021517

Wang (1990) Developing selective inhibitors of calpain. TiPS 11 139 PMID: 2185586

If you know of a relevant reference for Leupeptin hemisulfate, please let us know.

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Keywords: Leupeptin hemisulfate, supplier, inhibitors, inhibits, trypsin-like, cysteine, proteases, Proteases, Proteinases, Other, Proteases, Other, Proteases, Tocris Bioscience

1 Citation for Leupeptin hemisulfate

Citations are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:

Haller et al (2015) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. J Pharmacol Exp Ther 10 2269 PMID: 25629932

Do you know of a great paper that uses Leupeptin hemisulfate from Tocris? If so please let us know.

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