Leupeptin hemisulfate

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Description: Inhibits trypsin-like/cysteine proteases
Purity: ≥95% (HPLC)
Citations (2)
Reviews (1)

Biological Activity for Leupeptin hemisulfate

Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.

Technical Data for Leupeptin hemisulfate

M. Wt 475.6
Formula C20H38N6O4.½H2SO4
Sequence LLR

(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 103476-89-7
PubChem ID 2733491
Smiles OS(O)(=O)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Leupeptin hemisulfate

Solubility Soluble to 10 mg/ml in water

Product Datasheets for Leupeptin hemisulfate

Certificate of Analysis / Product Datasheet
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References for Leupeptin hemisulfate

References are publications that support the biological activity of the product.

Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150 PMID: 1877091

Sarin et al (1994) Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J.Immunol. 153 862 PMID: 8021517

Wang (1990) Developing selective inhibitors of calpain. TiPS 11 139 PMID: 2185586

If you know of a relevant reference for Leupeptin hemisulfate, please let us know.

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Keywords: Leupeptin hemisulfate, Leupeptin hemisulfate supplier, inhibitors, inhibits, trypsin-like, cysteine, proteases, Proteases, Proteinases, Other, 1167, Tocris Bioscience

2 Citations for Leupeptin hemisulfate

Citations are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:

Berg et al (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep 27 2837 PMID: 31167131

Haller et al (2015) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. J Pharmacol Exp Ther 10 2269 PMID: 25629932

Do you know of a great paper that uses Leupeptin hemisulfate from Tocris? Please let us know.

Reviews for Leupeptin hemisulfate

Average Rating: 5 (Based on 1 Review.)

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Happy with results.
By Estela Correa on 07/27/2022
Assay Type: Ex Vivo
Species: Mouse

I used it as a protease inhibitor. Concentration of 1:1000.

Be careful when measuring weight. Very light material.