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Biological Activity for Leupeptin hemisulfate
Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.
Technical Data for Leupeptin hemisulfate
(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Leupeptin hemisulfate
|Solubility||Soluble to 10 mg/ml in water|
Product Datasheets for Leupeptin hemisulfate
References for Leupeptin hemisulfate
References are publications that support the biological activity of the product.
Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150 PMID: 1877091
Sarin et al (1994) Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J.Immunol. 153 862 PMID: 8021517
Wang (1990) Developing selective inhibitors of calpain. TiPS 11 139 PMID: 2185586
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Keywords: Leupeptin hemisulfate, Leupeptin hemisulfate supplier, inhibitors, inhibits, trypsin-like, cysteine, proteases, Proteases, Proteinases, Other, 1167, Tocris Bioscience
2 Citations for Leupeptin hemisulfate
Citations are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:
Haller et al (2015) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. J Pharmacol Exp Ther 10 2269 PMID: 25629932
Berg et al (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep 27 2837 PMID: 31167131
Do you know of a great paper that uses Leupeptin hemisulfate from Tocris? Please let us know.
Reviews for Leupeptin hemisulfate
Average Rating: 4 (Based on 2 Reviews.)
Have you used Leupeptin hemisulfate?
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I have used this product as the protease inhibitor in my protein isolation cocktail mix.
We used Leupeptin hemisulfate as a protease inhibitor to restore surface antigen in cell suspension cultures. We've used it both in vitro and in vivo.