Leupeptin hemisulfate

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Cat.No. 1167 - Leupeptin hemisulfate | Ac-Leu-Leu-Arginal | CAS No. 103476-89-7
Description: Inhibits trypsin-like/cysteine proteases
Citations (2)
Reviews (1)
Literature (1)

Biological Activity

Reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.

Technical Data

M. Wt 475.04
Formula C20H38N6O4.½H2SO4
Sequence LLR

(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)

Storage Desiccate at -20°C
CAS Number 103476-89-7
PubChem ID 2733491
Smiles OS(O)(=O)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150 PMID: 1877091

Sarin et al (1994) Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J.Immunol. 153 862 PMID: 8021517

Wang (1990) Developing selective inhibitors of calpain. TiPS 11 139 PMID: 2185586

If you know of a relevant reference for Leupeptin hemisulfate, please let us know.

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Keywords: Leupeptin hemisulfate, Leupeptin hemisulfate supplier, inhibitors, inhibits, trypsin-like, cysteine, proteases, Proteases, Proteinases, Other, 1167, Tocris Bioscience

2 Citations for Leupeptin hemisulfate

Citations are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:

Berg et al (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep 27 2837 PMID: 31167131

Haller et al (2015) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. J Pharmacol Exp Ther 10 2269 PMID: 25629932

Do you know of a great paper that uses Leupeptin hemisulfate from Tocris? Please let us know.

Reviews for Leupeptin hemisulfate

Average Rating: 4 (Based on 1 Review.)

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effective protease inhibitor.
By Anonymous on 05/30/2018
Assay Type: In Vitro
Species: Mouse

We used Leupeptin hemisulfate as a protease inhibitor to restore surface antigen in cell suspension cultures. We've used it both in vitro and in vivo.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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