Reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.
(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 10 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 475.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.11 mL||10.53 mL||21.05 mL|
|5 mM||0.42 mL||2.11 mL||4.21 mL|
|10 mM||0.21 mL||1.05 mL||2.11 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References are publications that support the products' biological activity.
Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150 PMID: 1877091
Sarin et al (1994) Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J.Immunol. 153 862 PMID: 8021517
Wang (1990) Developing selective inhibitors of calpain. TiPS 11 139 PMID: 2185586
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Keywords: Leupeptin hemisulfate, supplier, inhibitors, inhibits, trypsin-like, cysteine, proteases, Proteases, Proteinases, Other, Proteases, Other, Proteases, Tocris Bioscience
1 Citation for Leupeptin hemisulfate
Citations are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:
Haller et al (2015) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. J Pharmacol Exp Ther 10 2269 PMID: 25629932
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