LDN 214117

Discontinued Product

LDN 214117 (Cat. No. 6152) has been withdrawn from sale for commercial reasons.
Cat.No. 6152 - LDN 214117 | C25H29N3O3 | CAS No. 1627503-67-6
Description: Potent and selective ALK2 inhibitor
Chemical Name: 1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)
Pathways (1)

Biological Activity for LDN 214117

LDN 214117 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptor ALK2 (IC50 = 24 nM). Shows preference for ALK1 and ALK2 over ALK3 and 164-fold selectivity for BMP6 inhibition (IC50 = 100 nM) over TGF-β1. Exhibits improved kinome selectivity over K 02288 (Cat.No. 4986) and low cytotoxicity.

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patent 14/776,302

Technical Data for LDN 214117

M. Wt 419.52
Formula C25H29N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1627503-67-6
PubChem ID 91754554
InChI Key BHUXVRVMMYAXKN-UHFFFAOYSA-N
Smiles COC1=CC(C2=C(N=CC(C3=CC=C(N4CCNCC4)C=C3)=C2)C)=CC(OC)=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for LDN 214117

References are publications that support the biological activity of the product.

Mohedas et al (2014) Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 57 7900 PMID: 25101911

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View all BMP and Other Activin Receptor Inhibitors

Keywords: LDN 214117, LDN 214117 supplier, LDN214117, Inhibitors, Inhibits, ALK1, ALK2, BMP, Bone, morphogenic, protein, BMP6, TGF-, β1, TGF-b1, TGF-beta1, kinase, activin, receptor-like, kinases, and, Other, Activin, Receptors, 6152, Tocris Bioscience

Citations for LDN 214117

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Currently there are no citations for LDN 214117.

Reviews for LDN 214117

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for LDN 214117

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.