LDN 193189

Pricing Availability   Qty
Description: LDN 193189 synthesized to cGMP guidelines
Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity: ≥99%
Protocols (3)
Literature (4)

Biological Activity for LDN 193189

LDN 193189 synthesized to cGMP guidelines. Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.

Research use only LDN 193189 also available.

Licensing Information

Sold for research purposes only under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484. A license may be required for use in stem cell-based therapies. Please contact Technical Support for further details: techsupport@bio-techne.com.

Current Good Manufacturing Practice (cGMP) is a harmonized set of guidelines that when implemented will ensure safe, reliable, consistent and quality-assured products. The Tocris range of cGMP small molecules is manufactured following relevant sections of ICH Q7 guidelines. Our highly skilled team has full control over the cGMP process, meaning we can ensure: a quality-assured manufacturing system, batch-to-batch consistency, consistent supply, traceability from starting material to final product, and animal-free production. Find out more about the Tocris range of cGMP compounds.

Technical Data for LDN 193189

M. Wt 479.4
Formula C25H22N6.2HCl
Storage Store at -20°C(±5°C)
Purity ≥99%
CAS Number 1435934-00-1
Smiles N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

This product is intended for research use or further manufacturing only.

Product Datasheets for LDN 193189

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for LDN 193189

References are publications that support the biological activity of the product.

If you know of a relevant reference for LDN 193189, please let us know.

Keywords: LDN 193189, LDN 193189 supplier, LDN193189, dihydrochloride, BMP, signaling, ALK2, ALK3, activin, bone, morphogenetic, proteins, stem, cells, neural, differentiation, neurons, GMP, Small, Molecules, TB6053-GMP, Tocris Bioscience

Citations for LDN 193189

Citations are publications that use Tocris products.

Currently there are no citations for LDN 193189. Do you know of a great paper that uses LDN 193189 from Tocris? Please let us know.

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Protocols for LDN 193189

The following protocols feature additional information for the use of LDN 193189 (Cat. No. TB6053-GMP).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.