Lazabemide hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2460 - Lazabemide hydrochloride | C8H10ClN3O.HCl | CAS No. 103878-83-7
Description: Selective MAO-B inhibitor
Alternative Names: Ro 19-6327
Chemical Name: N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC50 values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).

Compound Libraries

Lazabemide hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 236.1
Formula C8H10ClN3O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 103878-83-7
PubChem ID 163727
InChI Key JMFKTFLARGGXCC-UHFFFAOYSA-N
Smiles Cl.NCCNC(=O)C1=NC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.61 100
water 23.61 100

Preparing Stock Solutions

The following data is based on the product molecular weight 236.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.24 mL 21.18 mL 42.35 mL
5 mM 0.85 mL 4.24 mL 8.47 mL
10 mM 0.42 mL 2.12 mL 4.24 mL
50 mM 0.08 mL 0.42 mL 0.85 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Saura et al (1992) Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J.Neurosci. 12 1977 PMID: 1578281

Bondiolotti et al (1995) In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem.Pharmacol. 50 97 PMID: 7605351

Guimaraes and Soares-da-Silva (1998) The activity of MAO A and B in rat renal cells and tubules. Life Sci. 62 727 PMID: 9489509


If you know of a relevant reference for Lazabemide hydrochloride, please let us know.

View Related Products by Product Action

View all Monoamine Oxidase Inhibitors

Keywords: Lazabemide hydrochloride, supplier, Selective, MAO-B, inhibitors, inhibits, Monoamine, Oxygenases, Oxidases, Ro196327, Ro, 19-6327, Monoamine, Oxidase, Adrenergic, Related, Compounds, Dopaminergic-Related, 5-HT-Related, 5-HT3, Receptors, Monoamine, Oxidase, Tocris Bioscience

Citations for Lazabemide hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Lazabemide hydrochloride. Do you know of a great paper that uses Lazabemide hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for Lazabemide hydrochloride

Protocols

TODO: Add Protocols