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Lazabemide hydrochloride is a selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC50 values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 236.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.24 mL||21.18 mL||42.35 mL|
|5 mM||0.85 mL||4.24 mL||8.47 mL|
|10 mM||0.42 mL||2.12 mL||4.24 mL|
|50 mM||0.08 mL||0.42 mL||0.85 mL|
References are publications that support the biological activity of the product.
Saura et al (1992) Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J.Neurosci. 12 1977 PMID: 1578281
Bondiolotti et al (1995) In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem.Pharmacol. 50 97 PMID: 7605351
Guimaraes and Soares-da-Silva (1998) The activity of MAO A and B in rat renal cells and tubules. Life Sci. 62 727 PMID: 9489509
If you know of a relevant reference for Lazabemide hydrochloride, please let us know.
Keywords: Lazabemide hydrochloride, Lazabemide hydrochloride supplier, Selective, MAO-B, inhibitors, inhibits, Monoamine, Oxygenases, Oxidases, Ro196327, Ro, 19-6327, Oxidase, Adrenergic, Related, Compounds, Dopaminergic-Related, 5-HT-Related, 5-HT3, Receptors, 2460, Tocris Bioscience
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