Lavendustin A

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Cat.No. 1331 - Lavendustin A | C21H19NO6 | CAS No. 125697-92-9
Description: EGFR, p60c-src inhibitor
Alternative Names: RG 14355
Chemical Name: 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM).

Technical Data

M. Wt 381.38
Formula C21H19NO6
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 125697-92-9
PubChem ID 11317883
InChI Key JJSYXNQGLHBRRK-SFEDZAPPSA-N
Smiles OC1=CC=C(O)C=C1CN(CC3=C(O)C=CC=C3)C2=CC=C(O)C(C(O)=O)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.53 25
ethanol 9.53 25

Preparing Stock Solutions

The following data is based on the product molecular weight 381.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.11 mL 26.22 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hsu et al (1991) Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J.Biol.Chem. 266 21105 PMID: 1939153

O'Dell et al (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558 PMID: 1656271

Onoda et al (1989) Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J.Nat.Prod. 52 1252 PMID: 2614420


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Literature in this Area

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Pathways for Lavendustin A

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