Lansoprazole

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Cat.No. 2582 - Lansoprazole | C16H14F3N3O2S | CAS No. 103577-45-3
Description: H+,K+-ATPase inhibitor
Alternative Names: AG-1749
Chemical Name: 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

H+,K+-ATPase inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (Cat. No. 2583).

Technical Data

M. Wt 369.36
Formula C16H14F3N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 103577-45-3
PubChem ID 3883
InChI Key MJIHNNLFOKEZEW-UHFFFAOYSA-N
Smiles CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 18.47 50
DMSO 36.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 369.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References

References are publications that support the biological activity of the product.

Satoh et al (1989) Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806 PMID: 2537418

Schmarda et al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598 PMID: 10711360

Matheson and Jarvis (2001) Lansoprazole. Drugs 61 1801 PMID: 11693467


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Keywords: Lansoprazole, Lansoprazole supplier, H+K+-ATPase, inhibitors, inhibits, Hydrogen, Potassium-ATPase, Ion, Transporters, Pumps, ATPases, AG1749, AG-1749, H+,K+-ATPase, 2582, Tocris Bioscience

Citations for Lansoprazole

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