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Cat.No. 2582 - Lansoprazole | C16H14F3N3O2S | CAS No. 103577-45-3
Description: H+,K+-ATPase inhibitor
Alternative Names: AG-1749
Chemical Name: 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
Purity: ≥99% (HPLC)

Biological Activity for Lansoprazole

Lansoprazole is a H+,K+-ATPase inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (Cat. No. 2583).

Technical Data for Lansoprazole

M. Wt 369.36
Formula C16H14F3N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 103577-45-3
PubChem ID 3883
Smiles CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lansoprazole

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 18.47 50
DMSO 36.94 100

Preparing Stock Solutions for Lansoprazole

The following data is based on the product molecular weight 369.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for Lansoprazole

References are publications that support the biological activity of the product.

Satoh et al (1989) Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806 PMID: 2537418

Schmarda et al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598 PMID: 10711360

Matheson and Jarvis (2001) Lansoprazole. Drugs 61 1801 PMID: 11693467

If you know of a relevant reference for Lansoprazole, please let us know.

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Keywords: Lansoprazole, Lansoprazole supplier, H+K+-ATPase, inhibitors, inhibits, Hydrogen, Potassium-ATPase, Ion, Transporters, Pumps, ATPases, AG1749, AG-1749, H+,K+-ATPase, 2582, Tocris Bioscience

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