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Submit ReviewAntagonist of mGlu receptor-mediated phosphoinositide responses; stimulatory effects also observed. Inhibitor of phosphoserine phosphatase (less potent than D-isomer (0272)).
M. Wt | 169.07 |
Storage | Store at RT |
CAS Number | 23052-80-4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Irving et al (1990) 1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons. Eur.J.Pharmacol. 186 363 PMID: 2289537
Mistry et al (1996) Stimulatory effects of the putative metabotropic glutamate receptor antagonist L-AP3 on phosphoinositide turnover. Br.J.Pharmacol. 117 1309 PMID: 8882630
Schoepp et al (1990) Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. Mol.Pharmacol. 38 222 PMID: 2166902
Schoepp and Conn (1993) Metabotropic glutamate receptors in brain function and pathology. TiPS 14 13 PMID: 7680175
View all Glutamate (Metabotropic) Group I Receptor Antagonists
Keywords: L-AP3, L-AP3 supplier, Glutamate, (Metabotropic), Group, I, Receptors, 0273, Tocris Bioscience
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