L-AP3

Discontinued Product

L-AP3 (Cat. No. 0273) has been withdrawn from sale for commercial reasons.
Description: Group I mGlu antagonist
Chemical Name: L(+)-2-Amino-3-phosphonopropionic acid
Datasheet
Citations
Reviews
Literature (6)

Biological Activity for L-AP3

Antagonist of mGlu receptor-mediated phosphoinositide responses; stimulatory effects also observed. Inhibitor of phosphoserine phosphatase (less potent than D-isomer (0272)).

Technical Data for L-AP3

M. Wt 169.07
Storage Store at RT
CAS Number 23052-80-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for L-AP3

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for L-AP3

References are publications that support the biological activity of the product.

Irving et al (1990) 1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons. Eur.J.Pharmacol. 186 363 PMID: 2289537

Mistry et al (1996) Stimulatory effects of the putative metabotropic glutamate receptor antagonist L-AP3 on phosphoinositide turnover. Br.J.Pharmacol. 117 1309 PMID: 8882630

Schoepp et al (1990) Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. Mol.Pharmacol. 38 222 PMID: 2166902

Schoepp and Conn (1993) Metabotropic glutamate receptors in brain function and pathology. TiPS 14 13 PMID: 7680175

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Keywords: L-AP3, L-AP3 supplier, Glutamate, (Metabotropic), Group, I, Receptors, 0273, Tocris Bioscience

Citations for L-AP3

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Currently there are no citations for L-AP3.

Reviews for L-AP3

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Huntington's Disease Poster

Huntington's Disease Poster

Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

Learning & Memory Poster

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.