KU 60019

Pricing Availability   Qty
Cat.No. 4176 - KU 60019 | C30H33N3O5S | CAS No. 925701-46-8
Description: Potent ATM kinase inhibitor
Chemical Name: (2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (11)
Reviews
Literature

Biological Activity

Potent ATM kinase inhibitor (IC50 = 6.3 nM). Exhibits little to no nonspecific target effects against a panel of 229 protein kinases; displays similar target selectivity to KU 55933 (Cat. No. 3544). Inhibits migration and invasion of human glioma cells in vitro.

Licensing Information

Sold with the permission of AstraZeneca.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KU 60019 is reviewed on the chemical probes website.

Compound Libraries

KU 60019 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 547.67
Formula C30H33N3O5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 925701-46-8
PubChem ID 15953870
InChI Key SCELLOWTHJGVIC-BGYRXZFFSA-N
Smiles O=C(CN4C[C@H](C)O[C@H](C)C4)NC(C=C3)=CC2=C3SC1=C(C5=CC(C=C(N6CCOCC6)O5)=O)C=CC=C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 54.77 100
DMSO 54.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 547.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL
10 mM 0.18 mL 0.91 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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References

References are publications that support the biological activity of the product.

Golding et al (2009) Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol.Cancer Ther. 8 2894 PMID: 19808981


If you know of a relevant reference for KU 60019, please let us know.

View Related Products by Product Action

View all ATM and ATR Kinase Inhibitors

Keywords: KU 60019, KU 60019 supplier, Astrazeneca, KU60019, atm, kinases, ataxia, telangiectasia, mutated, potent, inhibitors, inhibits, ATM, &, ATR, Kinase, Checkpoint, Control, Kinases, 4176, Tocris Bioscience

11 Citations for KU 60019

Citations are publications that use Tocris products. Selected citations for KU 60019 include:

Rass et al (2013) Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem 288 7086 PMID: 23355489

Müllers et al (2014) Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. Cell Cycle 13 2733 PMID: 25486360

Wu et al (2014) Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. J Biol Chem 289 34378 PMID: 25336634

Gautam (2013) The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication. J Virol 87 8687 PMID: 23740981

Deng et al (2016) Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways. PLoS Pathog 12 e1005399 PMID: 26765330

Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Biol Chem 64 4361 PMID: 23963679

Mehta et al (2015) Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators. PLoS Pathog 11 e1004763 PMID: 25875106

Koo et al (2015) RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression. Nucleic Acids Res 290 7463 PMID: 25623070

Parplys et al (2015) NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Cell Cycle 43 9817 PMID: 26323318

Davari et al (2014) Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle 13 3659 PMID: 25483076

Barton et al (2014) Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol 206 877 PMID: 25267294


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Literature in this Area

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Cancer

Cancer Research Product Guide

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • PI-3 Kinase, Akt and mTOR
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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.