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Description: HSF1 inhibitor
Chemical Name: N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for KRIBB11

KRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo.

Technical Data for KRIBB11

M. Wt 284.27
Formula C13H12N6O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 342639-96-7
PubChem ID 69894253
Smiles CNC1=NC(NC2=CC=C(NN=C3)C3=C2)=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KRIBB11

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.43 100

Preparing Stock Solutions for KRIBB11

The following data is based on the product molecular weight 284.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.59 mL 35.18 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for KRIBB11

References are publications that support the biological activity of the product.

Yoon et al (2011) KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J.Biol.Chem. 286 1737 PMID: 21078672

Samarasinghe et al (2014) Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem. Pharmacol. 87 445 PMID: 24291777

If you know of a relevant reference for KRIBB11, please let us know.

Keywords: KRIBB11, KRIBB11 supplier, HSF1, inhibitors, inhibits, heat, shock, factors, 1, HSP90, HSP70, HSP27, proteins, Hsp90, Hsp70, Other, Transcription, Factors, 5480, Tocris Bioscience

Citations for KRIBB11

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