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KJ Pyr 9
Biological Activity for KJ Pyr 9
KJ Pyr 9 is a high affinity Myc inhibitor (Kd = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant.
Technical Data for KJ Pyr 9
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for KJ Pyr 9
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for KJ Pyr 9
The following data is based on the product molecular weight 385.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.59 mL||12.97 mL||25.95 mL|
|5 mM||0.52 mL||2.59 mL||5.19 mL|
|10 mM||0.26 mL||1.3 mL||2.59 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References for KJ Pyr 9
References are publications that support the biological activity of the product.
Hart et al (2014) Inhibitor of MYC identified in a Kröhnke pyridine library. Proc.Natl.Acad.Sci.U.S.A. 111 12556 PMID: 25114221
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2 Citations for KJ Pyr 9
Citations are publications that use Tocris products. Selected citations for KJ Pyr 9 include:
Chau et al (2018) Downregulation of ribosome biogenesis during early forebrain development. Elife. e36998 PMID: 29745900
Ana et al (2020) Acute liver failure is regulated by MYC- and microbiome-dependent programs. Nat Med 26 1899-1911 PMID: 33106666
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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