KC 12291 hydrochloride

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Cat.No. 3251 - KC 12291 hydrochloride | C22H27N3O3S.HCl | CAS No. 181936-98-1
Description: Orally active atypical Na+ channel blocker; cardioprotective
Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.

Technical Data

M. Wt 449.99
Formula C22H27N3O3S.HCl
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 181936-98-1
PubChem ID 22902387
InChI Key KIJPRQYBNQKUAU-UHFFFAOYSA-N
Smiles CN(CCCOC2=NSC(C3=CC=CC=C3)=N2)CCC1=CC=C(OC)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.5 50
water 11.25 25

Preparing Stock Solutions

The following data is based on the product molecular weight 449.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.11 mL 22.22 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346 PMID: 12198320

John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17 PMID: 14978516

Letienne et al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243 PMID: 16368090

Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358 547


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Citations for KC 12291 hydrochloride

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