KC 12291 hydrochloride

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Cat.No. 3251 - KC 12291 hydrochloride | C22H27N3O3S.HCl | CAS No. 181936-98-1
Description: Orally active atypical Na+ channel blocker; cardioprotective
Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride
Purity: ≥97% (HPLC)
Literature (5)

Biological Activity for KC 12291 hydrochloride

KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.

Technical Data for KC 12291 hydrochloride

M. Wt 449.99
Formula C22H27N3O3S.HCl
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 181936-98-1
PubChem ID 22902387

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KC 12291 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 11.25 25
DMSO 22.5 50

Preparing Stock Solutions for KC 12291 hydrochloride

The following data is based on the product molecular weight 449.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.44 mL 22.22 mL 44.45 mL
2.5 mM 0.89 mL 4.44 mL 8.89 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
25 mM 0.09 mL 0.44 mL 0.89 mL

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Product Datasheets for KC 12291 hydrochloride

References for KC 12291 hydrochloride

References are publications that support the biological activity of the product.

Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346 PMID: 12198320

John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17 PMID: 14978516

Letienne et al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243 PMID: 16368090

Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358 547

If you know of a relevant reference for KC 12291 hydrochloride, please let us know.

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Citations for KC 12291 hydrochloride

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