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Cat.No. 2287 - K-252c | C20H13N3O | CAS No. 85753-43-1
Description: Protein kinase C inhibitor
Alternative Names: Staurosporinone
Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Purity: ≥99% (HPLC)
Citations (1)
Literature (3)

Biological Activity for K-252c

K-252c is an inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).

Technical Data for K-252c

M. Wt 311.34
Formula C20H13N3O
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 85753-43-1
PubChem ID 3815
Smiles O=C(NC3)C1=C3C(C4=CC=CC=C4N5)=C5C2=C1C6=C(C=CC=C6)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for K-252c

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.78 25

Preparing Stock Solutions for K-252c

The following data is based on the product molecular weight 311.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 12.85 mL 64.24 mL 128.48 mL
1.25 mM 2.57 mL 12.85 mL 25.7 mL
2.5 mM 1.28 mL 6.42 mL 12.85 mL
12.5 mM 0.26 mL 1.28 mL 2.57 mL

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References for K-252c

References are publications that support the biological activity of the product.

Fabre et al (1993) Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg.Med.Chem. 1 193 PMID: 8081852

Zimmermann et al (2000) Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 48 49 PMID: 11080540

McGovern and Shoichet (2003) Kinase inhibitors: not just for kinases anymore. J.Med.Chem. 46 1478 PMID: 12672248

If you know of a relevant reference for K-252c, please let us know.

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Keywords: K-252c, K-252c supplier, Protein, kinases, C, inhibitors, inhibits, PKC, Staurosporinone, Kinase, Cytomegalovirus, 2287, Tocris Bioscience

1 Citation for K-252c

Citations are publications that use Tocris products. Selected citations for K-252c include:

Goldman et al (2012) An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol 19 855 PMID: 22840773

Do you know of a great paper that uses K-252c from Tocris? Please let us know.

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Literature in this Area

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