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Biological Activity for JX 401
JX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
Compound Libraries for JX 401
Technical Data for JX 401
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JX 401
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JX 401
The following data is based on the product molecular weight 355.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||3.75 mL||18.75 mL||37.51 mL|
|3.75 mM||0.75 mL||3.75 mL||7.5 mL|
|7.5 mM||0.38 mL||1.88 mL||3.75 mL|
|37.5 mM||0.08 mL||0.38 mL||0.75 mL|
References for JX 401
References are publications that support the biological activity of the product.
Friedmann et al (2006) JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 70 1395 PMID: 16847144
If you know of a relevant reference for JX 401, please let us know.
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Keywords: JX 401, JX 401 supplier, Potent, reversible, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, JX401, p38, 2657, Tocris Bioscience
Citations for JX 401
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Reviews for JX 401
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.