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Submit ReviewJX 401
Discontinued Product
JX 401 (Cat. No. 2657) has been withdrawn from sale for commercial reasons.
Description: Potent, reversible p38α inhibitor
Chemical Name: 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
Purity: ≥98% (HPLC)
Biological Activity for JX 401
JX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
Compound Libraries for JX 401
JX 401 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for JX 401
| M. Wt | 355.49 |
| Formula | C21H25NO2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 349087-34-9 |
| PubChem ID | 1126109 |
| InChI Key | OMGLGPKQUFSRNN-UHFFFAOYSA-N |
| Smiles | COC1=C(C=CC(SC)=C1)C(=O)N1CCC(CC2=CC=CC=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JX 401
References for JX 401
References are publications that support the biological activity of the product.
Friedmann et al (2006) JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 70 1395 PMID: 16847144
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Keywords: JX 401, JX 401 supplier, Potent, reversible, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, JX401, p38, 2657, Tocris Bioscience
Citations for JX 401
Citations are publications that use Tocris products.
Currently there are no citations for JX 401.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for JX 401
