Potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 355.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.81 mL||14.07 mL||28.13 mL|
|5 mM||0.56 mL||2.81 mL||5.63 mL|
|10 mM||0.28 mL||1.41 mL||2.81 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References are publications that support the products' biological activity.
Friedmann et al (2006) JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 70 1395 PMID: 16847144
If you know of a relevant reference for JX 401, please let us know.
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Keywords: JX 401, supplier, Potent, reversible, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, JX401, p38, p38, Tocris Bioscience
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Literature in this Area
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.