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Submit ReviewJW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amide hydrolase (IC50 = 20.6 μM). Analog of JZL 195 (Cat. No. 4715).
Sold under license from The Scripps Research Institute
M. Wt | 462.39 |
Formula | C21H20F6N2O3 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 1416133-89-5 |
PubChem ID | 71656520 |
InChI Key | AVSCNEOUWSVZEY-UHFFFAOYSA-N |
Smiles | O=C(OC(C(F)(F)F)C(F)(F)F)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 46.24 | 100 | |
ethanol | 46.24 | 100 |
The following data is based on the product molecular weight 462.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.16 mL | 10.81 mL | 21.63 mL |
5 mM | 0.43 mL | 2.16 mL | 4.33 mL |
10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
References are publications that support the biological activity of the product.
Chang et al (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 19 579 PMID: 22542104
If you know of a relevant reference for JW 642, please let us know.
Keywords: JW 642, JW 642 supplier, JW642, MAGL, monoacylglycerol, potent, selective, inhibitors, inhibits, lipases, esterases, 4906, Tocris Bioscience
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