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Submit ReviewJW 642
Description: MAGL inhibitor
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Purity: ≥98% (HPLC)
Biological Activity for JW 642
JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amide hydrolase (IC50 = 20.6 μM). Analog of JZL 195 (Cat. No. 4715).
Licensing Information
Sold under license from The Scripps Research Institute
Technical Data for JW 642
| M. Wt | 462.39 |
| Formula | C21H20F6N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1416133-89-5 |
| PubChem ID | 71656520 |
| InChI Key | AVSCNEOUWSVZEY-UHFFFAOYSA-N |
| Smiles | O=C(OC(C(F)(F)F)C(F)(F)F)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JW 642
References for JW 642
References are publications that support the biological activity of the product.
Chang et al (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 19 579 PMID: 22542104
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Keywords: JW 642, JW 642 supplier, JW642, MAGL, monoacylglycerol, potent, selective, inhibitors, inhibits, lipases, esterases, 4906, Tocris Bioscience
Citations for JW 642
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