JW 642

Pricing Availability Delivery Time Qty
Cat.No. 4906 - JW 642 | C21H20F6N2O3 | CAS No. 1416133-89-5
Description: MAGL inhibitor
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amide hydrolase (IC50 = 20.6 μM). Analog of JZL 195 (Cat. No. 4715).

Licensing Information

Sold under license from The Scripps Research Institute

Compound Libraries

JW 642 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 462.39
Formula C21H20F6N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1416133-89-5
PubChem ID 71656520
InChI Key AVSCNEOUWSVZEY-UHFFFAOYSA-N
Smiles O=C(OC(C(F)(F)F)C(F)(F)F)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.24 100
ethanol 46.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 462.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.81 mL 21.63 mL
5 mM 0.43 mL 2.16 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chang et al (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 19 579 PMID: 22542104


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Keywords: JW 642, supplier, JW642, MAGL, monoacylglycerol, potent, selective, inhibitors, inhibits, lipases, esterases, MAGL, MAGL, Tocris Bioscience

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