JNJ 17203212

Pricing Availability   Qty
Cat.No. 3361 - JNJ 17203212 | C17H15F6N5O | CAS No. 821768-06-3
Description: Reversible, competitive and potent TRPV1 antagonist
Chemical Name: 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity

Reversible, competitive and potent TRPV1 antagonist (pKi values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H+-induced channel activation (pIC50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo.

Compound Libraries

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Technical Data

M. Wt 419.32
Formula C17H15F6N5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 821768-06-3
PubChem ID 11339118
InChI Key JFRYYGVYCWYIDQ-UHFFFAOYSA-N
Smiles O=C(NC3=NC=C(C(F)(F)F)C=C3)N(CC2)CCN2C1=C(C(F)(F)F)C=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.93 100
ethanol 41.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 419.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.85 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Keywords: JNJ 17203212, JNJ 17203212 supplier, Reversible, competitive, potent, TRPV1, antagonists, Vanillioid, Receptors, VR1, Channels, Transient, Receptor, Potential, JNJ17203212, TRPV, 3361, Tocris Bioscience

2 Citations for JNJ 17203212

Citations are publications that use Tocris products. Selected citations for JNJ 17203212 include:

Kelly et al (2015) Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. PLoS One 74 252 PMID: 24152419

Vijayvergiya et al (2015) Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers. PLoS One 10 e0141366 PMID: 26513481


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Literature in this Area

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.