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Biological Activity for JH-XI-10-02
JH-XI-10-02 is a CDK8 Degrader comprising the cereblon binding ligand Pomalidomide (Cat. No. 6302) joined by a linker to a CDK8 inhibitor. JH-XI-10-02 (1 μM) induces significant proteasome-dependent degradation of CDK8 in Jurkat cells after 24 h, with no significant effect on CDK19 levels.
Sold under license from Dana-Farber Cancer Institute.
Technical Data for JH-XI-10-02
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JH-XI-10-02
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JH-XI-10-02
The following data is based on the product molecular weight 920.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||2.17 mL||10.87 mL||21.74 mL|
|2.5 mM||0.43 mL||2.17 mL||4.35 mL|
|5 mM||0.22 mL||1.09 mL||2.17 mL|
|25 mM||0.04 mL||0.22 mL||0.43 mL|
References for JH-XI-10-02
References are publications that support the biological activity of the product.
Hatcher et al (2018) Development of highly potent and selective steroidal inhibitors and degraders of CDK8. ACS Med.Chem.Lett. 9 540 PMID: 29937979
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Keywords: JH-XI-10-02, JH-XI-10-02 supplier, CDK8, degraders, protacs, cyclin-dependent, kinases, targeted, protein, degradation, TPD, degrades, Active, Degraders, Transcriptional, CDKs, 7304, Tocris Bioscience
Citations for JH-XI-10-02
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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