Discontinued Product

Ivachtin (Cat. No. 2636) has been withdrawn from sale for commercial reasons.
Cat.No. 2636 - Ivachtin | C20H21N3O7S | CAS No. 745046-84-8
Description: Potent caspase-3 inhibitor
Chemical Name: 2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate
Purity: ≥99% (HPLC)
Literature (6)

Biological Activity for Ivachtin

Potent, reversible inhibitor of caspase-3 (IC50 = 23 nM) that displays moderate selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine; exhibits a higher level of protection than Z-VAD-FMK (Cat. No. 2163).

Licensing Information

Sold with the permission of ChemDiv, Inc.

Technical Data for Ivachtin

M. Wt 447.46
Formula C20H21N3O7S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 745046-84-8
Smiles CC(=O)OCCN1C(=O)C2=C(C)N=C3C=CC(=CC3=C2C1=O)S(=O)(=O)N1CCOCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Ivachtin

References are publications that support the biological activity of the product.

Kravchenko et al (2005) Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J.Med.Chem. 48 3680 PMID: 15916416

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Keywords: Ivachtin, Ivachtin supplier, Potent, caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2636, Tocris Bioscience

Citations for Ivachtin

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Currently there are no citations for Ivachtin.

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