Ispinesib

Pricing Availability Delivery Time Qty
Cat.No. 5408 - Ispinesib | C30H33ClN4O2 | CAS No. 336113-53-2
Description: High affinity and selective allosteric KSP inhibitor
Alternative Names: SB 715992
Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice.

Compound Libraries

Ispinesib is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 517.06
Formula C30H33ClN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 336113-53-2
PubChem ID 6851740
InChI Key QJZRFPJCWMNVAV-HHHXNRCGSA-N
Smiles O=C2N(CC3=CC=CC=C3)C([C@@H]([C@@H](C)C)N(CCCN)C(C4=CC=C(C)C=C4)=O)=NC1=CC(Cl)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.71 100
ethanol 51.71 100

Preparing Stock Solutions

The following data is based on the product molecular weight 517.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.67 mL 19.34 mL
5 mM 0.39 mL 1.93 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lad et al (2008) Mechanism of inhibition of human KSP by ispinesib. Biochemistry 47 3576 PMID: 18290633

Davis et al (2006) Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer 6 22 PMID: 16433906

Purcell et al (2010) Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin.Cancer Res. 16 566 PMID: 20068098


If you know of a relevant reference for Ispinesib, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Kinesin Inhibitors

Keywords: Ispinesib, supplier, SB715992, CK0238273, high, affinity, selective, potent, allosteric, kinesin, spindle, protein, KSP, hsEG5, SB, 715992, Kinesin, Kinesin, Tocris Bioscience

Citations for Ispinesib

Citations are publications that use Tocris products.

Currently there are no citations for Ispinesib. Do you know of a great paper that uses Ispinesib from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Ispinesib

Protocols

TODO: Add Protocols