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Description: High affinity and selective allosteric KSP inhibitor
Alternative Names: SB 715992
Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Ispinesib

Ispinesib is a high affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice.

Compound Libraries for Ispinesib

Ispinesib is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ispinesib

M. Wt 517.06
Formula C30H33ClN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 336113-53-2
PubChem ID 6851740
Smiles O=C2N(CC3=CC=CC=C3)C([C@@H]([C@@H](C)C)N(CCCN)C(C4=CC=C(C)C=C4)=O)=NC1=CC(Cl)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ispinesib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.71 100
ethanol 51.71 100

Preparing Stock Solutions for Ispinesib

The following data is based on the product molecular weight 517.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.67 mL 19.34 mL
5 mM 0.39 mL 1.93 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for Ispinesib

References are publications that support the biological activity of the product.

Lad et al (2008) Mechanism of inhibition of human KSP by ispinesib. Biochemistry 47 3576 PMID: 18290633

Davis et al (2006) Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer 6 22 PMID: 16433906

Purcell et al (2010) Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin.Cancer Res. 16 566 PMID: 20068098

If you know of a relevant reference for Ispinesib, please let us know.

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Keywords: Ispinesib, Ispinesib supplier, SB715992, CK0238273, high, affinity, selective, potent, allosteric, kinesin, spindle, protein, KSP, hsEG5, SB, 715992, Kinesin, 5408, Tocris Bioscience

Citations for Ispinesib

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Literature in this Area

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

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