Isoguvacine hydrochloride

Pricing Availability   Qty
Description: Selective GABAA agonist
Chemical Name: 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
Purity: ≥99% (HPLC)
Citations (5)
Literature (2)

Biological Activity for Isoguvacine hydrochloride

Isoguvacine hydrochloride is a specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.

Technical Data for Isoguvacine hydrochloride

M. Wt 163.6
Formula C6H9NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 68547-97-7
PubChem ID 155107
Smiles Cl.OC(=O)C=1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Isoguvacine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for Isoguvacine hydrochloride

The following data is based on the product molecular weight 163.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.11 mL 30.56 mL 61.12 mL
5 mM 1.22 mL 6.11 mL 12.22 mL
10 mM 0.61 mL 3.06 mL 6.11 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

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Product Datasheets for Isoguvacine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Isoguvacine hydrochloride

References are publications that support the biological activity of the product.

Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377 PMID: 670980

Krogsgaard-Larsen et al (1979) Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 32 1717 PMID: 448364

Wahab et al (2009) Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 86 113 PMID: 19535226

If you know of a relevant reference for Isoguvacine hydrochloride, please let us know.

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Keywords: Isoguvacine hydrochloride, Isoguvacine hydrochloride supplier, Selective, GABAA, agonists, Receptors, 0235, Tocris Bioscience

5 Citations for Isoguvacine hydrochloride

Citations are publications that use Tocris products. Selected citations for Isoguvacine hydrochloride include:

Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. Br J Pharmacol 284 8726 PMID: 19141616

Sipilä et al (2009) Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci 29 6982 PMID: 19474325

Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons. J Neurophysiol 104 403 PMID: 20445035

Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260 PMID: 20691150

Do you know of a great paper that uses Isoguvacine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.