Isoguvacine hydrochloride

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Cat.No. 0235 - Isoguvacine hydrochloride | C6H9NO2.HCl | CAS No. 68547-97-7
Description: Selective GABAA agonist
Chemical Name: 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.

Technical Data

M. Wt 163.6
Formula C6H9NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 68547-97-7
PubChem ID 155107
InChI Key SUWREQRNTXCCBL-UHFFFAOYSA-N
Smiles Cl.OC(=O)C=1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 163.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.11 mL 30.56 mL 61.12 mL
5 mM 1.22 mL 6.11 mL 12.22 mL
10 mM 0.61 mL 3.06 mL 6.11 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377 PMID: 670980

Krogsgaard-Larsen et al (1979) Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 32 1717 PMID: 448364

Wahab et al (2009) Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 86 113 PMID: 19535226


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Keywords: Isoguvacine hydrochloride, supplier, Selective, GABAA, agonists, Receptors, GABAA, Receptors, Tocris Bioscience

5 Citations for Isoguvacine hydrochloride

Citations are publications that use Tocris products. Selected citations for Isoguvacine hydrochloride include:

Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. Br J Pharmacol 284 8726 PMID: 19141616

Sipilä et al (2009) Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci 29 6982 PMID: 19474325

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci 131 1050 PMID: 11082110

Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260 PMID: 20691150

Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol 104 403 PMID: 20445035


Do you know of a great paper that uses Isoguvacine hydrochloride from Tocris? If so please let us know.

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Pathways for Isoguvacine hydrochloride

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