IRL-1620

Discontinued Product

IRL-1620 (Cat. No. 1196) has been withdrawn from sale for commercial reasons.
Description: Highly selective ETB agonist
Purity: ≥95% (HPLC)
Datasheet
Citations (8)
Reviews

Biological Activity for IRL-1620

IRL-1620 is a potent and highly selective ETB endothelin receptor agonist (Ki values are 0.016 and 1900 nM at ETB and ETA receptors respectively). Discriminates two subpopulations of ETB receptors. IRL-1620 prevents oxidative stress and cognitive impairment induced by Aβ in normal and diabetic rats; in a rat brain ischemia model it is neuroprotective, increases angiogenesis and neurogenesis, and promotes the recovery of neuronal function. Also promotes neural progenitor cell differentiation and maturation in vivo and in vitro.

Technical Data for IRL-1620

M. Wt 1820
Formula C86H117N17O27
Sequence DEEAVYFAHLDIIW

(Modifications: Asp-1 = Suc-Asp)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 142569-99-1
PubChem ID 16130933
InChI Key DXPHNGAMYPPTBJ-TZMIJSMNSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for IRL-1620

Certificate of Analysis / Product Datasheet
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Keywords: IRL-1620, IRL-1620 supplier, IRL1620, selective, ETB, agonists, Receptors, Endothelinb, alzheimers, Abeta, AB, Aβ, angiogenesis, neurogenesis, neuroprotective, Endothelin, Neural, Stem, Cells, 1196, Tocris Bioscience

8 Citations for IRL-1620

Citations are publications that use Tocris products. Selected citations for IRL-1620 include:

Choisy et al (2012) Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart. PLoS One 7 e33448 PMID: 22479400

Mazzuca et al (2013) Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca2+]i in mesenteric microvessels of pregnant rats. Br J Pharmacol 169 1335 PMID: 23646960

Ou et al (2014) Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol 229 489 PMID: 24105843

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510


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