IQ 1

Pricing Availability Delivery Time Qty
Cat.No. 4713 - IQ 1 | C21H22N4O2 | CAS No. 331001-62-8
Description: Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation
Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.

Compound Libraries

IQ 1 is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 362.42
Formula C21H22N4O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 331001-62-8
PubChem ID 56801
InChI Key XTZNCVSCVHTPAI-UHFFFAOYSA-N
Smiles CC(C(C=C3)=CC=C3/N=N/C(C(N)=O)=C2\C1=CC=CC=C1CC(C)(C)N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.24 100
ethanol 7.25 20

Preparing Stock Solutions

The following data is based on the product molecular weight 362.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.59 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Miyabayashi et al (2007) Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc.Natl.Acad.Sci.U S A 104 5668 PMID: 17372190


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View Related Products by Target

Keywords: IQ1 embryonic stem cells ESCs pluripotency dedifferentiation maintains cultured Wnt3a blocks differentiation PP2A Nkd Oct4 Sox2 Stem Cell Proliferation

1 Citation for IQ 1

Citations are publications that use Tocris products. Selected citations for IQ 1 include:

Long et al (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. J Neurosci 7 10354 PMID: 26838601


Do you know of a great paper that uses IQ 1 from Tocris? If so please let us know.

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Literature in this Area

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Cancer Research Product Guide

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Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for IQ 1

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