IQ 1

Discontinued Product

IQ 1 (Cat. No. 4713) has been withdrawn from sale for commercial reasons.
Description: Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation
Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide
Purity: ≥99% (HPLC)
Citations (3)
Literature (4)

Biological Activity for IQ 1

IQ 1 is a maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.

Technical Data for IQ 1

M. Wt 362.42
Formula C21H22N4O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 331001-62-8
PubChem ID 56801
Smiles CC(C(C=C3)=CC=C3/N=N/C(C(N)=O)=C2\C1=CC=CC=C1CC(C)(C)N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for IQ 1

References are publications that support the biological activity of the product.

Miyabayashi et al (2007) Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc.Natl.Acad.Sci.U S A 104 5668 PMID: 17372190

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Keywords: IQ 1, IQ 1 supplier, IQ1, embryonic, stem, cells, ESCs, pluripotency, dedifferentiation, maintains, cultured, Wnt3a, blocks, differentiation, PP2A, Nkd, Oct4, Sox2, Stem, Cell, Proliferation, 4713, Tocris Bioscience

3 Citations for IQ 1

Citations are publications that use Tocris products. Selected citations for IQ 1 include:

Koopmans et al (2016) Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle. Br J Pharmacol 173 3327 PMID: 27629364

Koopmans et al (2017) β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle. Front Immunol 8 1086 PMID: 28943877

Long et al (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. J Neurosci 7 10354 PMID: 26838601

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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