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5-HT receptor agonist with high affinity for 5-HT1A receptors (pKd = 7.8) and lower affinity for 5-HT1B and 5-HT2C receptors (pKd values are 5.44 and 6.49 respectively). Possesses anti-hypertensive, anxiolytic and anorectic activity in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Velazquez-Martinez et al (1999) Discriminative stimulus properties of indorenate, a serotonin agonist. J.Psychiatry Neurosci. 24 122 PMID: 10212554
Sanchez and Velazquez-Martinez (2001) Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats. J.Psychopharmacol. 15 29 PMID: 11277605
Miranda et al (2003) Further evidence that the discriminative stimulus properties of indorenate are mediated by 5-HT1A/1B/2C receptors. Pharmacol.Biochem.Behav. 74 371 PMID: 12479957
Keywords: Indorenate hydrochloride, Indorenate hydrochloride supplier, 5-HT1A, 5-HT1B, 5-HT2C, agonists, Serotonin, Receptors, TR3369, TR, 3369, 2399, Tocris Bioscience
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.