Indorenate hydrochloride

Discontinued Product

Unfortunately Indorenate hydrochloride (Cat. No. 2399) has been withdrawn from sale for commercial reasons.
Cat.No. 2399 - Indorenate hydrochloride | C13H16N2O3.HCl | CAS No. 72318-55-9
Description: 5-HT1A, 5-HT1B and 5-HT2C agonist
Alternative Names: TR 3369
Chemical Name: α-(Aminomethyl)-5-methoxy-1H-indole-3-acetic acid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT receptor agonist with high affinity for 5-HT1A receptors (pKd = 7.8) and lower affinity for 5-HT1B and 5-HT2C receptors (pKd values are 5.44 and 6.49 respectively). Possesses anti-hypertensive, anxiolytic and anorectic activity in vivo.

Technical Data

M. Wt 284.74
Formula C13H16N2O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 72318-55-9
Smiles NCC(C(OC)=O)C2=CNC1=CC=C(OC)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 284.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.56 mL 35.12 mL
5 mM 0.7 mL 3.51 mL 7.02 mL
10 mM 0.35 mL 1.76 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References

References are publications that support the products' biological activity.

Velazquez-Martinez et al (1999) Discriminative stimulus properties of indorenate, a serotonin agonist. J.Psychiatry Neurosci. 24 122 PMID: 10212554

Sanchez and Velazquez-Martinez (2001) Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats. J.Psychopharmacol. 15 29 PMID: 11277605

Miranda et al (2003) Further evidence that the discriminative stimulus properties of indorenate are mediated by 5-HT1A/1B/2C receptors. Pharmacol.Biochem.Behav. 74 371 PMID: 12479957

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Keywords: Indorenate hydrochloride, supplier, 5-HT1A, 5-HT1B, 5-HT2C, agonists, Serotonin, Receptors, TR3369, TR, 3369, 5-HT1B, Receptors, Tocris Bioscience

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