Indorenate hydrochloride

Discontinued Product

Indorenate hydrochloride (Cat. No. 2399) has been withdrawn from sale for commercial reasons.
Description: 5-HT1A, 5-HT1B and 5-HT2C agonist
Alternative Names: TR 3369
Chemical Name: α-(Aminomethyl)-5-methoxy-1H-indole-3-acetic acid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Indorenate hydrochloride

5-HT receptor agonist with high affinity for 5-HT1A receptors (pKd = 7.8) and lower affinity for 5-HT1B and 5-HT2C receptors (pKd values are 5.44 and 6.49 respectively). Possesses anti-hypertensive, anxiolytic and anorectic activity in vivo.

Technical Data for Indorenate hydrochloride

M. Wt 284.74
Formula C13H16N2O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 72318-55-9
Smiles NCC(C(OC)=O)C2=CNC1=CC=C(OC)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Indorenate hydrochloride

References for Indorenate hydrochloride

References are publications that support the biological activity of the product.

Velazquez-Martinez et al (1999) Discriminative stimulus properties of indorenate, a serotonin agonist. J.Psychiatry Neurosci. 24 122 PMID: 10212554

Sanchez and Velazquez-Martinez (2001) Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats. J.Psychopharmacol. 15 29 PMID: 11277605

Miranda et al (2003) Further evidence that the discriminative stimulus properties of indorenate are mediated by 5-HT1A/1B/2C receptors. Pharmacol.Biochem.Behav. 74 371 PMID: 12479957

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Keywords: Indorenate hydrochloride, Indorenate hydrochloride supplier, 5-HT1A, 5-HT1B, 5-HT2C, agonists, Serotonin, Receptors, TR3369, TR, 3369, 2399, Tocris Bioscience

Citations for Indorenate hydrochloride

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Currently there are no citations for Indorenate hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.