INCB 024360-analog

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Cat.No. 6007 - INCB 024360-analog | C9H7ClFN5O2 | CAS No. 914471-09-3
Description: Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
Chemical Name: 4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable.

Technical Data

M. Wt 271.64
Formula C9H7ClFN5O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 914471-09-3
PubChem ID 11978742
InChI Key MUVQOOPKPBEAJZ-VQHVLOKHSA-N
Smiles O/N=C(NC1=CC(Cl)=C(F)C=C1)/C2=NON=C2N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.16 100
ethanol 27.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 271.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.68 mL 18.41 mL 36.81 mL
5 mM 0.74 mL 3.68 mL 7.36 mL
10 mM 0.37 mL 1.84 mL 3.68 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Weinmann (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578

Yue et al (2009) Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J.Med.Chem. 52 7364 PMID: 19507862

Dounay et al (2015) Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway. J.Med.Chem. 58 8762 PMID: 26207924


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Keywords: INCB 024360-analog, supplier, 1, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, IDO, IDO, Tocris Bioscience

Citations for INCB 024360-analog

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