ID 8

Discontinued Product

ID 8 (Cat. No. 3853) has been withdrawn from sale for commercial reasons.
Description: Sustains self-renewal and pluripotency of ESCs
Chemical Name: 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity for ID 8

ID 8 is a sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period). Also supports human PSC maintenance in combiantions with Wnt3a. DYRK inhibitor

Technical Data for ID 8

M. Wt 298.29
Formula C16H14N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 147591-46-6
PubChem ID 791637
Smiles CC2=C([N+]([O-])=O)C1=CC=C(O)C=C1N2C3=CC=C(OC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ID 8

References are publications that support the biological activity of the product.

Miyabayashi et al (2008) Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci.Biotechnol.Biochem. 72 1242 PMID: 18460821

Firestone and Chen (2009) Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS Chem.Biol. 5 15

Hasegawa et al (2012) Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl.Med. 1 18 PMID: 23197636

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Citations for ID 8

Citations are publications that use Tocris products.

Currently there are no citations for ID 8.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.