IC 87201

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Cat.No. 6226 - IC 87201 | C13H10Cl2N4O | CAS No. 866927-10-8
Description: nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant
Chemical Name: 2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Inhibits binding of the NMDA receptor postsynaptic density protein 95 kDa (PSD95) to nNOS (EC50 = 23.94 μM), while not affecting the PSD95-ErbB4 interaction. Inhibits glutamate-induced cell death in cultured cortical neurons. Exhibits antinociceptive effects in inflammatory pain models in vivo. Also exhibits antidepressant-like activitiy in animal models.

Technical Data

M. Wt 309.15
Formula C13H10Cl2N4O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 866927-10-8
PubChem ID 11771269
InChI Key QEHVTUCLCBXQIC-UHFFFAOYSA-N
Smiles OC1=C(C=C(C=C1Cl)Cl)CNC2=CC=C3N=NNC3=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO and to 100 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 309.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.23 mL 16.17 mL 32.35 mL
5 mM 0.65 mL 3.23 mL 6.47 mL
10 mM 0.32 mL 1.62 mL 3.23 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Doucet et al (2013) Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice. Neuropsychopharmacology. 38 1575 PMID: 23446451

Lee et al (2015) Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics. Neuropharmacology. 97 464 PMID: 26071110

Florio et al (2009) Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents. Br.J.Pharmacol. 158 494 PMID: 19732061


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Keywords: IC 87201, supplier, IC87201, postsynaptic, density, protein, 95, PSD95, nNOS, NMDA, protein-protein, interactions, inhibitors, inhibits, binding, antinociceptive, antidepressant, NMDA, Receptors, nNOS, NMDA, Receptors, Tocris Bioscience

1 Citation for IC 87201

Citations are publications that use Tocris products. Selected citations for IC 87201 include:

PMID:


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