You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for IC 261
IC 261 is an ATP-competitive casein kinase 1 (CK1) inhibitor. Displays >15 fold selectivity for CK1δ and CK1ε over CK1α (IC50 values are approximately 1 μM for CK1δ and CK1ε and 16 μM for CK1α). Arrests cell cycle at postmitotic G1 phase in cells expressing p53. Inhibits CK1 mediated phosphorylation of LRRK2 in cell lines.
Technical Data for IC 261
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for IC 261
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for IC 261
The following data is based on the product molecular weight 311.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.21 mL||16.06 mL||32.12 mL|
|5 mM||0.64 mL||3.21 mL||6.42 mL|
|10 mM||0.32 mL||1.61 mL||3.21 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References for IC 261
References are publications that support the biological activity of the product.
Behrend et al (2000) IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene 19 5303 PMID: 11103931
Mashhoon et al (2000) Crystal structure of a conformation-selective casein kinase-1 inhibitor. J.Med.Chem. 275 20052 PMID: 10749871
Chia et al (2014) Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat.Commun. 5 5827 PMID: 25500533
If you know of a relevant reference for IC 261, please let us know.
View Related Products by Product Action
Keywords: IC 261, IC 261 supplier, IC261, casein, kinase, 1, CK1, inhibitor, inhibits, CK1delta, CK1epsilon, Casein, Kinase, 6676, Tocris Bioscience
Citations for IC 261
Citations are publications that use Tocris products.
Currently there are no citations for IC 261. Do you know of a great paper that uses IC 261 from Tocris? Please let us know.
Reviews for IC 261
There are currently no reviews for this product. Be the first to review IC 261 and earn rewards!
Have you used IC 261?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.