HX 630

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Cat.No. 3913 - HX 630 | C28H27NO2S | CAS No. 188844-52-2
Description: RXR synergist
Chemical Name: 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

RXR agonist. Acts as a retinoid synergist; enhances the potency of AM 80 (Cat. No. 3507) in a HL-60 cell differentiation assay.

Licensing Information

Sold under licence.

Technical Data

M. Wt 441.58
Formula C28H27NO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 188844-52-2
PubChem ID 9889522
InChI Key PFGCWQPTOKPRRK-UHFFFAOYSA-N
Smiles CC3(C)CCC(C)(C)C(C3=C4)=CC2=C4C(C5=CC=C(C(O)=O)C=C5)=NC1=CC=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.08 50

Preparing Stock Solutions

The following data is based on the product molecular weight 441.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.32 mL 22.65 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Umemiya et al (1997) Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J.Med.Chem. 40 4222 PMID: 9435893

Ohashi et al (2002) Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines. J.Vet.Med.Sci. 64 169 PMID: 11913557

Ishida et al (2003) Clinically potential subclasses of retinoid synergists revealed by gene expression profiling. Mol.Cancer Ther. 2 49 PMID: 12533672


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View Related Products by Target

Keywords: HX630 synergists retinoids retinoic pan-RXR agonists retinoid synergist Retinoid X Receptor

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Literature in this Area

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Retinoid Receptors

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

Pathways for HX 630

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