HX 630

Discontinued Product

HX 630 (Cat. No. 3913) has been withdrawn from sale for commercial reasons.
Description: RXR synergist
Chemical Name: 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for HX 630

HX 630 is a RXR agonist. Acts as a retinoid synergist; enhances the potency of AM 80 (Cat. No. 3507) in a HL-60 cell differentiation assay.

Licensing Information

Sold under licence.

Technical Data for HX 630

M. Wt 441.58
Formula C28H27NO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 188844-52-2
PubChem ID 9889522
Smiles CC3(C)CCC(C)(C)C(C3=C4)=CC2=C4C(C5=CC=C(C(O)=O)C=C5)=NC1=CC=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for HX 630

References are publications that support the biological activity of the product.

Umemiya et al (1997) Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J.Med.Chem. 40 4222 PMID: 9435893

Ohashi et al (2002) Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines. J.Vet.Med.Sci. 64 169 PMID: 11913557

Ishida et al (2003) Clinically potential subclasses of retinoid synergists revealed by gene expression profiling. Mol.Cancer Ther. 2 49 PMID: 12533672

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Keywords: HX 630, HX 630 supplier, HX630, synergists, retinoids, retinoic, pan-RXR, agonists, retinoid, synergist, Retinoid, X, Receptor, 3913, Tocris Bioscience

Citations for HX 630

Citations are publications that use Tocris products.

Currently there are no citations for HX 630.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.