HX 630

Pricing Availability   Qty
Description: RXR synergist
Chemical Name: 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for HX 630

HX 630 is a RXR agonist. Acts as a retinoid synergist; enhances the potency of AM 80 (Cat. No. 3507) in a HL-60 cell differentiation assay.

Licensing Information

Sold under licence.

Technical Data for HX 630

M. Wt 441.58
Formula C28H27NO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 188844-52-2
PubChem ID 9889522
InChI Key PFGCWQPTOKPRRK-UHFFFAOYSA-N
Smiles CC3(C)CCC(C)(C)C(C3=C4)=CC2=C4C(C5=CC=C(C(O)=O)C=C5)=NC1=CC=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HX 630

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.08 50

Preparing Stock Solutions for HX 630

The following data is based on the product molecular weight 441.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.53 mL 22.65 mL 45.29 mL
2.5 mM 0.91 mL 4.53 mL 9.06 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
25 mM 0.09 mL 0.45 mL 0.91 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for HX 630

References are publications that support the biological activity of the product.

Umemiya et al (1997) Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J.Med.Chem. 40 4222 PMID: 9435893

Ohashi et al (2002) Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines. J.Vet.Med.Sci. 64 169 PMID: 11913557

Ishida et al (2003) Clinically potential subclasses of retinoid synergists revealed by gene expression profiling. Mol.Cancer Ther. 2 49 PMID: 12533672


If you know of a relevant reference for HX 630, please let us know.

View Related Products by Target

Keywords: HX 630, HX 630 supplier, HX630, synergists, retinoids, retinoic, pan-RXR, agonists, retinoid, synergist, Retinoid, X, Receptor, 3913, Tocris Bioscience

Citations for HX 630

Citations are publications that use Tocris products.

Currently there are no citations for HX 630. Do you know of a great paper that uses HX 630 from Tocris? Please let us know.

Reviews for HX 630

There are currently no reviews for this product. Be the first to review HX 630 and earn rewards!

Have you used HX 630?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.