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HX 630

Cat. No. 3913 Submit a Review Datasheet / COA / SDS
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Description: RXR synergist
Chemical Name: 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for HX 630

HX 630 is a RXR agonist. Acts as a retinoid synergist; enhances the potency of AM 80 (Cat. No. 3507) in a HL-60 cell differentiation assay.

Licensing Information

Sold under licence.

Technical Data for HX 630

M. Wt 441.58
Formula C28H27NO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 188844-52-2
PubChem ID 9889522
InChI Key PFGCWQPTOKPRRK-UHFFFAOYSA-N
Smiles CC3(C)CCC(C)(C)C(C3=C4)=CC2=C4C(C5=CC=C(C(O)=O)C=C5)=NC1=CC=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HX 630

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.08 50

Preparing Stock Solutions for HX 630

The following data is based on the product molecular weight 441.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.53 mL 22.65 mL 45.29 mL
2.5 mM 0.91 mL 4.53 mL 9.06 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
25 mM 0.09 mL 0.45 mL 0.91 mL

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References for HX 630

References are publications that support the biological activity of the product.

Umemiya et al (1997) Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J.Med.Chem. 40 4222 PMID: 9435893

Ohashi et al (2002) Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines. J.Vet.Med.Sci. 64 169 PMID: 11913557

Ishida et al (2003) Clinically potential subclasses of retinoid synergists revealed by gene expression profiling. Mol.Cancer Ther. 2 49 PMID: 12533672

If you know of a relevant reference for HX 630, please let us know.

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Citations for HX 630

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.