Huwentoxin XVI

Pricing Availability   Qty
Cat.No. 5235 - Huwentoxin XVI | Cys-Ile-Gly-Glu-Gly-Val-Pro-Cys-Asp-Glu-Asn-Asp-Pro-Arg-Cys-Cys-Ser-Gly-Leu-Val-Cys-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys-Tyr-Lys-Lys | CAS No. 1600543-88-1
Description: Potent and reversible CaV2.2 blocker
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective N-type Ca2+ channel blocker (IC50 ~ 60 nM); selectively and reversibly blocks N-type Ca2+ channels. Does not block T-type Ca2+ channels, K+ channels or Na+ channels. Exhibits analgesic effects in vivo.

Technical Data

M. Wt 4437.13
Formula C196H292N50O56S6
Sequence CIGEGVPCDENDPRCCSGLVCLKPTLHGIWYKSYYCYKK

(Modifications: Disulfide bridge: 1-16,8-21,15-36)

Storage Store at -20°C
CAS Number 1600543-88-1
PubChem ID 90489025
InChI Key JEUFUDFTZMBKGH-UHFFFAOYSA-N
Smiles [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N3)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Deng et al (2014) Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena. Neuropharmacology 79 657 PMID: 24467846

Jiang et al (2010) Venomics of the spider Ornithoctonus huwena based on transcriptomic versus proteomic analysis. Comp.Biochem.Physiol.Part D Genomics Proteomics 5 81 PMID: 20403776


If you know of a relevant reference for Huwentoxin XVI, please let us know.

View Related Products by Product Action

View all CaV2.x Channel Blockers

Keywords: Huwentoxin XVI, Huwentoxin XVI supplier, Huwentoxin, 16, Potent, selective, N, type, Ca2+, channel, blockers, reversible, analgesics, venoms, Cav2.x, Channels, 5235, Tocris Bioscience

Citations for Huwentoxin XVI

Citations are publications that use Tocris products.

Currently there are no citations for Huwentoxin XVI. Do you know of a great paper that uses Huwentoxin XVI from Tocris? Please let us know.

Reviews for Huwentoxin XVI

There are currently no reviews for this product. Be the first to review Huwentoxin XVI and earn rewards!

Have you used Huwentoxin XVI?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Neurotransmission

Neurotransmission Product Guide

A collection of over 250 products for neurotransmission research, the guide includes research tools for the study of:

  • Dopaminergic Transmission
  • Glutamatergic Transmission
  • Opioid Peptide Transmission
  • Serotonergic Transmission
  • Chemogenetics
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling