Potent and selective NUAK1 inhibitor (IC50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells in vitro, to a similar extent as NUAK1 knockdown models.
Sold under license from Dana-Farber Cancer Institute
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 468.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.13 mL||10.67 mL||21.34 mL|
|5 mM||0.43 mL||2.13 mL||4.27 mL|
|10 mM||0.21 mL||1.07 mL||2.13 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the products' biological activity.
Banerjee et al (2014) Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 457 215 PMID: 24171924
If you know of a relevant reference for HTH 01-015, please let us know.
View Related Products by Product Action
Keywords: HTH 01-015, supplier, HTH01-015, potent, selective, NUAK1, family, SNF1-like, kinase-1, inhibitors, inhibits, NUAK, NUAK, Tocris Bioscience
Citations for HTH 01-015
Citations are publications that use Tocris products.
Currently there are no citations for HTH 01-015. Do you know of a great paper that uses HTH 01-015 from Tocris? If so please let us know.
Reviews for HTH 01-015
There are currently no reviews for this product. Be the first to review HTH 01-015 and earn rewards!
Have you used HTH 01-015?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.