HPI 1

Pricing Availability   Qty
Description: Inhibits Hedgehog signaling
Chemical Name: 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity for HPI 1

HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling.

Technical Data for HPI 1

M. Wt 463.52
Formula C27H29NO6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 599150-20-6
PubChem ID 2926768
InChI Key ZXSWZQSYZYMZKS-UHFFFAOYSA-N
Smiles CC2=C(C(OCCOC)=O)C(C3=CC(O)=CC=C3)C1=C(N2)CC(C4=C(OC)C=CC=C4)CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HPI 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.35 100
ethanol 46.35 100

Preparing Stock Solutions for HPI 1

The following data is based on the product molecular weight 463.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.57 mL
5 mM 0.43 mL 2.16 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for HPI 1

References are publications that support the biological activity of the product.

Hyman et al (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.USA 106 14132 PMID: 19666565


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Keywords: HPI 1, HPI 1 supplier, HPI1, Hedgehog, Hh, signaling, signalling, inhibitors, inhibits, Gli1, Gli2, Sonic, Shh, SmoM2, Signaling, 3839, Tocris Bioscience

1 Citation for HPI 1

Citations are publications that use Tocris products. Selected citations for HPI 1 include:

Ling et al (2021) Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell 28 1090-1104.e6 PMID: 33915081


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Reviews for HPI 1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Stem Cell Research Product Guide

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Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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