HomoAMPA
Discontinued Product
Unfortunately HomoAMPA (Cat. No. 1026) has been withdrawn from sale for commercial reasons.
Biological Activity
The higher homolog of AMPA, this compound is completely inactive at ionotropic glutamate receptors but instead is a relatively potent and highly mGlu6 subtype-selective metabotropic glutamate receptor agonist.
Technical Data
| M. Wt | 200.19 |
| Formula | C8H12N2O4 |
| Storage | Store at RT |
| Smiles | Cc1c(CCC(C(=O)O)N)c(no1)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 200.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5 mL | 24.98 mL | 49.95 mL |
| 5 mM | 1 mL | 5 mL | 9.99 mL |
| 10 mM | 0.5 mL | 2.5 mL | 5 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Brauner-Osbourne et al (1996) A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazole-4-yl)butyric acid. J.Med.Chem. 39 3188 PMID: 8759641
View Related Products by Target
View Related Products by Product Action
View all Glutamate (Metabotropic) Group III Receptor Agonists
Keywords: Potent selective mGlu6 agonists mGlur Group III Receptors mGluR6 Glutamate Metabotropic Glutamate (Metabotropic) Group III Receptors
Citations for HomoAMPA
Citations are publications that use Tocris products.
Currently there are no citations for HomoAMPA.
Literature in this Area
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Parkinson's Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia PosterNew
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.
