HomoAMPA

Discontinued Product

Unfortunately HomoAMPA (Cat. No. 1026) has been withdrawn from sale for commercial reasons.
Cat.No. 1026 - HomoAMPA | C8H12N2O4
Description: Potent, highly selective mGlu6 agonist
Chemical Name: 2-Amino-4-(3-hydroxy-5-methylisoxazole-4-yl)butyric acid
Datasheet
Citations
Literature

Biological Activity

The higher homolog of AMPA, this compound is completely inactive at ionotropic glutamate receptors but instead is a relatively potent and highly mGlu6 subtype-selective metabotropic glutamate receptor agonist.

Technical Data

M. Wt 200.19
Formula C8H12N2O4
Storage Store at RT
Smiles Cc1c(CCC(C(=O)O)N)c(no1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 200.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5 mL 24.98 mL 49.95 mL
5 mM 1 mL 5 mL 9.99 mL
10 mM 0.5 mL 2.5 mL 5 mL
50 mM 0.1 mL 0.5 mL 1 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Brauner-Osbourne et al (1996) A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazole-4-yl)butyric acid. J.Med.Chem. 39 3188 PMID: 8759641

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Citations for HomoAMPA

Citations are publications that use Tocris products.

Currently there are no citations for HomoAMPA.

Commented out for usability testing

Reviews

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Literature in this Area

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Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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Pathways for HomoAMPA

Protocols

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