Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 182.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.49 mL||27.44 mL||54.88 mL|
|5 mM||1.1 mL||5.49 mL||10.98 mL|
|10 mM||0.55 mL||2.74 mL||5.49 mL|
|50 mM||0.11 mL||0.55 mL||1.1 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Ernsberger et al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35 PMID: 10415895
Glover et al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209 PMID: 7130973
Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057 PMID: 10725251
If you know of a relevant reference for Harmane, please let us know.
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Keywords: MAO-A MAO-B inhibitors inhibits putative endogenous imidazolines ligand MAO monoamine oxygenases oxidases I1 I2 Harman General Imidazolines
Citations for Harmane
Citations are publications that use Tocris products.
Currently there are no citations for Harmane. Do you know of a great paper that uses Harmane from Tocris? If so please let us know.
Literature in this Area
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