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Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 182.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||54.88 mL||274.39 mL||548.79 mL|
|0.5 mM||10.98 mL||54.88 mL||109.76 mL|
|1 mM||5.49 mL||27.44 mL||54.88 mL|
|5 mM||1.1 mL||5.49 mL||10.98 mL|
References are publications that support the biological activity of the product.
Ernsberger et al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35 PMID: 10415895
Glover et al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209 PMID: 7130973
Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057 PMID: 10725251
Hudson et al (1999) Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites. Br.J.Pharmacol. 126 2P
Merck Index 12 4646
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Keywords: Harmane, Harmane supplier, MAO-A, MAO-B, inhibitors, inhibits, putative, endogenous, imidazolines, ligand, MAO, monoamine, oxygenases, oxidases, I1, I2, Harman, General, Imidazolines, Monoamine, Oxidase, Adrenergic, Related, Compounds, Dopaminergic-Related, 5-HT-Related, 5-HT3, Receptors, 1132, Tocris Bioscience
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