Harmane

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Cat.No. 1132 - Harmane | C12H10N2 | CAS No. 486-84-0
Description: Putative endogenous imidazoline ligand. Also MAO inhibitor
Alternative Names: Harman
Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).

Technical Data

M. Wt 182.22
Formula C12H10N2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 486-84-0
PubChem ID 5281404
InChI Key PSFDQSOCUJVVGF-UHFFFAOYSA-N
Smiles CC1=NC=CC2=C1NC1=C2C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 1.82 10
DMSO 21.87 100
ethanol 21.87 100

Preparing Stock Solutions

The following data is based on the product molecular weight 182.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.49 mL 27.44 mL 54.88 mL
5 mM 1.1 mL 5.49 mL 10.98 mL
10 mM 0.55 mL 2.74 mL 5.49 mL
50 mM 0.11 mL 0.55 mL 1.1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ernsberger et al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35 PMID: 10415895

Glover et al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209 PMID: 7130973

Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057 PMID: 10725251

Hudson et al (1999) Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites. Br.J.Pharmacol. 126 2P PMID:

Merck Index 12 4646 PMID:


If you know of a relevant reference for Harmane, please let us know.

View Related Products by Product Action

View all General Imidazoline Ligands

Keywords: MAO-A MAO-B inhibitors inhibits putative endogenous imidazolines ligand MAO monoamine oxygenases oxidases I1 I2 Harman General Imidazolines

Citations for Harmane

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New Product Guide (Spring/Summer 2017)

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