Efaroxan hydrochloride

Discontinued Product

Efaroxan hydrochloride (Cat. No. 0792) has been withdrawn from sale for commercial reasons.
Description: α2 antagonist and I1, I3 ligand
Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for Efaroxan hydrochloride

Efaroxan hydrochloride is a potent, highly selective α2 adrenoceptor antagonist and imidazoline I1 receptor ligand (pKi values are 7.87, 7.42, 5.74, 7.28 and < 5 for α 2A, α2B, α2C, I1, and I2 receptors respectively). Promotes insulin secretion, at a site distinct from I1 or I2 (the putative I3 receptor) in vitro and in vivo.

Technical Data for Efaroxan hydrochloride

M. Wt 252.74
Formula C13H16N2O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 89197-00-2
PubChem ID 11957548
Smiles Cl.CCC1(CC2=CC=CC=C2O1)C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Efaroxan hydrochloride

Certificate of Analysis is currently unavailable on-line.
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References for Efaroxan hydrochloride

References are publications that support the biological activity of the product.

Chapleo et al (1984) α-Adrenoceptor reagents 2. Effects of modification of the 1,4-benzodioxan ring system on α-adrenoceptor activity. J.Med.Chem. 27 570 PMID: 6143826

Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381 PMID: 9786027

Mayer and Taberner (2002) Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 454 95 PMID: 12409010

Olmos et al (1994) Imidazolines stimulate release of Ins from RIN-5AH cells independently from imidazoline I1 and I2 receptors. Eur.J.Pharmacol. 262 41 PMID: 7813577

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Citations for Efaroxan hydrochloride

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Currently there are no citations for Efaroxan hydrochloride.

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Literature in this Area

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