HA 1100 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2415 - HA 1100 hydrochloride | C14H17N3O3S.HCl | CAS No. 155558-32-0
Description: Cell-permeable, selective Rho-kinase inhibitor
Alternative Names: Hydroxyfasudil
Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.

Technical Data

M. Wt 343.83
Formula C14H17N3O3S.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 155558-32-0
PubChem ID 11371328
Smiles Cl.OC1=NC=CC2=C(C=CC=C12)S(=O)(=O)N1CCCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 6.88 20

Preparing Stock Solutions

The following data is based on the product molecular weight 343.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.54 mL 29.08 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.45 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Arai et al (1993) Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487 PMID: 8240400

Shimokawa et al (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc.Res. 43 1029 PMID: 10615430

Utsunomiya et al (2001) Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br.J.Pharmacol. 134 1724 PMID: 11739249

If you know of a relevant reference for HA 1100 hydrochloride, please let us know.

View Related Products by Product Action

View all Rho-Kinases Inhibitors

Keywords: HA 1100 hydrochloride, supplier, Cell-permeable, selective, Rho-kinase, inhibitors, inhibits, Rho-Associated, Coiled-Coil, Kinases, p160ROCK, ROK, Rho-Kinase, HA1100, hydrochloride, Hydroxyfasudil, Rho-kinases, Rho-kinases, Tocris Bioscience

1 Citation for HA 1100 hydrochloride

Citations are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:

Pearn et al (2012) Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology 116 352 PMID: 22198221

Do you know of a great paper that uses HA 1100 hydrochloride from Tocris? If so please let us know.

Reviews for HA 1100 hydrochloride

There are currently no reviews for this product. Be the first to review HA 1100 hydrochloride and earn rewards!

Have you used HA 1100 hydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases