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HA 1100 hydrochloride
Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 343.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||14.54 mL||72.71 mL||145.42 mL|
|1 mM||2.91 mL||14.54 mL||29.08 mL|
|2 mM||1.45 mL||7.27 mL||14.54 mL|
|10 mM||0.29 mL||1.45 mL||2.91 mL|
References are publications that support the biological activity of the product.
Arai et al (1993) Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487 PMID: 8240400
Shimokawa et al (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc.Res. 43 1029 PMID: 10615430
Utsunomiya et al (2001) Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br.J.Pharmacol. 134 1724 PMID: 11739249
If you know of a relevant reference for HA 1100 hydrochloride, please let us know.
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2 Citations for HA 1100 hydrochloride
Citations are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:
Kirschstein et al (2014) Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro. Acta Pharmacol Sin 35 74 PMID: 24122009
Pearn et al (2012) PropF. neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology 116 352 PMID: 22198221
Do you know of a great paper that uses HA 1100 hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.