Specific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|phosphate buffered saline||16.36||100|
Preparing Stock Solutions
The following data is based on the product molecular weight 163.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.11 mL||30.56 mL||61.12 mL|
|5 mM||1.22 mL||6.11 mL||12.22 mL|
|10 mM||0.61 mL||3.06 mL||6.11 mL|
|50 mM||0.12 mL||0.61 mL||1.22 mL|
References are publications that support the products' biological activity.
Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497
Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377 PMID: 670980
If you know of a relevant reference for Guvacine hydrochloride, please let us know.
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Keywords: Guvacine hydrochloride, supplier, Specific, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABA, Transporters, GABA, Transporters, Tocris Bioscience
1 Citation for Guvacine hydrochloride
Citations are publications that use Tocris products. Selected citations for Guvacine hydrochloride include:
Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260 PMID: 20691150
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