Guvacine hydrochloride

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Cat.No. 0234 - Guvacine hydrochloride | C6H9NO2.HCl | CAS No. 6027-91-4
Description: Specific GABA uptake inhibitor
Chemical Name: 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Specific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.

Technical Data

M. Wt 163.6
Formula C6H9NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 6027-91-4
PubChem ID 11957555
InChI Key FGNUNVVTHHKDAM-UHFFFAOYSA-N
Smiles Cl.O=C(C=1CNCCC1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 16.36 100
water 16.36 100

Preparing Stock Solutions

The following data is based on the product molecular weight 163.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.11 mL 30.56 mL 61.12 mL
5 mM 1.22 mL 6.11 mL 12.22 mL
10 mM 0.61 mL 3.06 mL 6.11 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497

Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377 PMID: 670980


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Keywords: Guvacine hydrochloride, supplier, Specific, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABA, Transporters, GABA, Transporters, Tocris Bioscience

1 Citation for Guvacine hydrochloride

Citations are publications that use Tocris products. Selected citations for Guvacine hydrochloride include:

Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260 PMID: 20691150


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