Guvacine hydrochloride

Discontinued Product

Guvacine hydrochloride (Cat. No. 0234) has been withdrawn from sale for commercial reasons.
Description: Specific GABA uptake inhibitor
Chemical Name: 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for Guvacine hydrochloride

Specific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.

Technical Data for Guvacine hydrochloride

M. Wt 163.6
Formula C6H9NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 6027-91-4
PubChem ID 11957555
InChI Key FGNUNVVTHHKDAM-UHFFFAOYSA-N
Smiles Cl.O=C(C=1CNCCC1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Guvacine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Guvacine hydrochloride

References are publications that support the biological activity of the product.

Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497

Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377 PMID: 670980

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Keywords: Guvacine hydrochloride, Guvacine hydrochloride supplier, Specific, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, 0234, Tocris Bioscience

1 Citation for Guvacine hydrochloride

Citations are publications that use Tocris products. Selected citations for Guvacine hydrochloride include:

Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260 PMID: 20691150


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.