Guanabenz acetate

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Cat.No. 0885 - Guanabenz acetate | C8H8Cl2N4.CH3CO2H | CAS No. 23256-50-0
Description: α2 agonist. Also I2 selective ligand
Chemical Name: [(2,6-Dichlorobenzylidene)amino]guanidine acetate
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

α2-adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand.

Technical Data

M. Wt 291.14
Formula C8H8Cl2N4.CH3CO2H
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 23256-50-0
PubChem ID 5702062
InChI Key MCSPBPXATWBACD-GAYQJXMFSA-N
Smiles CC(O)=O.ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.84 75

Preparing Stock Solutions

The following data is based on the product molecular weight 291.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.17 mL 34.35 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Evans and Anderson (1995) Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α2-adrenoceptors. Br.J.Pharmacol. 116 1557 PMID: 8564219

Holmes et al (1983) Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs 26 212 PMID: 6352237

Michel and Insel (1989) Are there multiple imidazoline binding sites? Trends Pharmacol.Sci. 10 342 PMID: 2690423

Merck Index 12 4585 PMID:


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Keywords: Guanabenz acetate, supplier, α2-adrenoceptor, alpha2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, a2-adrenergic, agonists, I2, selective, ligands, Adrenoceptors, Imidazoline, Adrenergic, Alpha-2, Receptors, I2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience

4 Citations for Guanabenz acetate

Citations are publications that use Tocris products. Selected citations for Guanabenz acetate include:

Hamamura et al (2015) Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. Proc Natl Acad Sci U S A 4 84 PMID: 25977571

Wan et al (2014) Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow. PLoS One 9 e105699 PMID: 25157407

Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Bone Joint Res 24 7745 PMID: 15342742

Ye et al (2013) Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome. J Korean Med Sci 110 141 PMID: 23248313


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