Guanabenz acetate

Pricing Availability   Qty
Description: α2 agonist. Also I2 selective ligand
Chemical Name: [(2,6-Dichlorobenzylidene)amino]guanidine acetate
Purity: ≥98% (HPLC)
Citations (5)
Literature (2)

Biological Activity for Guanabenz acetate

Guanabenz acetate is a α2-adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand.

Technical Data for Guanabenz acetate

M. Wt 291.14
Formula C8H8Cl2N4.CH3CO2H
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 23256-50-0
PubChem ID 5702062
Smiles CC(O)=O.ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Guanabenz acetate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.84 75

Preparing Stock Solutions for Guanabenz acetate

The following data is based on the product molecular weight 291.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.58 mL 22.9 mL 45.8 mL
3.75 mM 0.92 mL 4.58 mL 9.16 mL
7.5 mM 0.46 mL 2.29 mL 4.58 mL
37.5 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets for Guanabenz acetate

Certificate of Analysis / Product Datasheet
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References for Guanabenz acetate

References are publications that support the biological activity of the product.

Evans and Anderson (1995) Renal effects of infusion of rilmenidine and guan. in conscious dogs: contribution of peripheral and central nervous system α2-adrenoceptors. Br.J.Pharmacol. 116 1557 PMID: 8564219

Holmes et al (1983) Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs 26 212 PMID: 6352237

Michel and Insel (1989) Are there multiple imidazoline binding sites? Trends Pharmacol.Sci. 10 342 PMID: 2690423

Merck Index 12 4585

If you know of a relevant reference for Guanabenz acetate, please let us know.

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5 Citations for Guanabenz acetate

Citations are publications that use Tocris products. Selected citations for Guanabenz acetate include:

Hamamura et al (2015) Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. Proc Natl Acad Sci U S A 4 84 PMID: 25977571

Ye et al (2013) Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome. J Korean Med Sci 110 141 PMID: 23248313

Nevin et al (2017) Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes. Am J Hum Genet 100 617 PMID: 28366443

Wan et al (2014) Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow. PLoS One 9 e105699 PMID: 25157407

Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Bone Joint Res 24 7745 PMID: 15342742

Do you know of a great paper that uses Guanabenz acetate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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