This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details of GSK J5, a cell permeable inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.4 mL||11.98 mL||23.95 mL|
|5 mM||0.48 mL||2.4 mL||4.79 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kruidenier et al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488 404 PMID: 22842901
If you know of a relevant reference for GSK J5, please let us know.
View Related Products by Product Action
Keywords: GSKJ5 histone demethylases inhibitors inhibits UTX JMJD3 KDM6 H3K27 epigenetics Histone Demethylases
1 Citation for GSK J5
Citations are publications that use Tocris products. Selected citations for GSK J5 include:
Carey et al (2015) Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Int J Nanomedicine 518 413 PMID: 25487152
Do you know of a great paper that uses GSK J5 from Tocris? If so please let us know.
Literature in this Area
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases