GSK J2

Pricing Availability Delivery Time Qty
Cat.No. 4688 - GSK J2 | CAS No. 1394854-52-4
Description: Inactive isomer of GSK J1 (Cat. No. 4593)
Chemical Name: N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inactive control of GSK J1 (Cat No.4593) (IC50 > 100 μM for inhibition of JMJD3/UTX). Cell permeable ester derivative, GSK J5 (Cat. No. 4689), also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further details of GSK J2, an inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.

Compound Libraries

GSK J2 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 389.45
Formula C22H23N5O2
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1394854-52-4
PubChem ID 73010924
InChI Key LJIFOCRGDDQFJF-UHFFFAOYSA-N
Smiles O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 19.47 50
DMSO 38.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 389.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kruidenier et al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488 404 PMID: 22842901


If you know of a relevant reference for GSK J2, please let us know.

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View all Histone Demethylase Inhibitors

Keywords: GSKJ2 histone demethylases inhibitors inhibits UTX JMJD3 KDM6 H3K27 epigenetics Histone Demethylases

Citations for GSK J2

Citations are publications that use Tocris products.

Currently there are no citations for GSK J2. Do you know of a great paper that uses GSK J2 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases

Pathways for GSK J2

Protocols

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