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Description: Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
Chemical Name: N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester hydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for GSK J5 HCl

GSK J5 HCl is an inactive isomer of GSK J4 (Cat. No. 4594); also cell permeable ester derivative of the inactive control, GSK J2 (Cat. No. 4688).

Active Analog also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details of GSK J5, a cell permeable inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.

Compound Libraries for GSK J5 HCl

GSK J5 HCl is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK J5 HCl

M. Wt 453.97
Formula C24H27N5O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1797983-32-4
PubChem ID 126456082
Smiles O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)OCC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK J5 HCl

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.7 50

Preparing Stock Solutions for GSK J5 HCl

The following data is based on the product molecular weight 453.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.41 mL 22.03 mL 44.06 mL
2.5 mM 0.88 mL 4.41 mL 8.81 mL
5 mM 0.44 mL 2.2 mL 4.41 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

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References for GSK J5 HCl

References are publications that support the biological activity of the product.

Kruidenier et al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488 404 PMID: 22842901

If you know of a relevant reference for GSK J5 HCl, please let us know.

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Citations for GSK J5 HCl

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.