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Submit ReviewGSK 9311 hydrochloride
Description: Negative control for GSK 6853
Chemical Name: N-[2,3-Dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxybenzamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for GSK 9311 hydrochloride
GSK 9311 hydrochloride is a negative control for GSK 6853 (Cat. No. 6198)
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK 9311 probe summary on the SGC website.
Compound Libraries for GSK 9311 hydrochloride
GSK 9311 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for GSK 9311 hydrochloride
| M. Wt | 474 |
| Formula | C24H31N5O3.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2253733-09-2 |
| PubChem ID | 121232406 |
| InChI Key | WFXIHQFRQPGCCR-MRXNPFEDSA-N |
| Smiles | COC1=C(C(N(CC)C2=C(N3CCNC[C@H]3C)C=C4N(C(N(C4=C2)C)=O)C)=O)C=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK 9311 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 47.4 | 100 | |
| DMSO | 47.4 | 100 |
Preparing Stock Solutions for GSK 9311 hydrochloride
The following data is based on the product molecular weight 474. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.11 mL | 10.55 mL | 21.1 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.11 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for GSK 9311 hydrochloride
References for GSK 9311 hydrochloride
References are publications that support the biological activity of the product.
Bamborough et al (2016) GSK6853, a chemical probe for inhibition of the BRPF1 bromodomain. ACS Med.Chem.Lett. 7 552 PMID: 27326325
If you know of a relevant reference for GSK 9311 hydrochloride, please let us know.
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