GSK 2801

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Cat.No. 5635 - GSK 2801 | C20H21NO4S | CAS No. 1619994-68-1
Description: Selective BAZ2A and BAZ2B inhibitor
Chemical Name: 1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity for GSK 2801

GSK 2801 is a selective BAZ2A and BAZ2B inhibitor (IC50 values are 0.40 and 0.43 μM, respectively). Selective for BAZ2A/B over TAF1L and BRD9. Cell permeable and orally available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK 2801 probe summary on the SGC website.

External Portal Information for GSK 2801

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK2801 is reviewed on the chemical probes website.

Technical Data for GSK 2801

M. Wt 371.45
Formula C20H21NO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1619994-68-1
PubChem ID 73010930
InChI Key KHWCPNJRJCNVRI-UHFFFAOYSA-N
Smiles CCCOC1=CC2=C(C3=C(S(C)(=O)=O)C=CC=C3)C=C(C(C)=O)N2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 2801

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.57 50

Preparing Stock Solutions for GSK 2801

The following data is based on the product molecular weight 371.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.38 mL 26.92 mL 53.84 mL
2.5 mM 1.08 mL 5.38 mL 10.77 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

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References for GSK 2801

References are publications that support the biological activity of the product.

Chen et al (2015) Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B. J.Med.Chem PMID: 25799074


If you know of a relevant reference for GSK 2801, please let us know.

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Keywords: GSK 2801, GSK 2801 supplier, selective, bromodomain, inhibitors, inhibits, cell, permeable, orally, bioavailable, BAZ2A, BAZ2B, structural, genomics, consortium, SGC, GSK2801, Bromodomains, 5635, Tocris Bioscience

Citations for GSK 2801

Citations are publications that use Tocris products.

Currently there are no citations for GSK 2801. Do you know of a great paper that uses GSK 2801 from Tocris? Please let us know.

Reviews for GSK 2801

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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