You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued ProductGSK 1363089 (Cat. No. 6056) has been withdrawn from sale for commercial reasons.
Biological Activity for GSK 1363089
GSK 1363089 is a potent inhibitor of MET, VEGFR2, Ron and AXL (IC50 values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFRα and PDGFRβ. Inhibits migration and invasion of B16F10 melanoma cells in vitro. Suppresses B16F10 tumor growth and metastasis in mice. Orally available.
Technical Data for GSK 1363089
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for GSK 1363089
References are publications that support the biological activity of the product.
Myers et al (2016) AXL inhibitors in cancer: A medicinal chemistry perspective. J.Med.Chem. 59 3593 PMID: 26555154
Faria et al (2015) Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma. Cancer Res. 75 134 PMID: 25391241
Qian et al (2009) Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 69 8009 PMID: 19808973
View Related Products by Target
View Related Products by Product Action
Keywords: GSK 1363089, GSK 1363089 supplier, GSK1363089, potent, inhibitors, inhibits, HGF, VEGFR2, AXL, tyrosine, kinases, orally, available, XL880, EXEL2880, XL, 880, EXEL, 2880, Foretinib, MET, Receptors, VEGFR, FLT3, PDGFR, 6056, Tocris Bioscience
Citations for GSK 1363089
Citations are publications that use Tocris products.
Currently there are no citations for GSK 1363089.
Reviews for GSK 1363089
There are currently no reviews for this product. Be the first to review GSK 1363089 and earn rewards!
Have you used GSK 1363089?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.