GSK 1363089

Pricing Availability   Qty
Cat.No. 6056 - GSK 1363089 | C34H34F2N4O6 | CAS No. 849217-64-7
Description: Potent inhibitor of MET, VEGFR2, Ron and AXL
Alternative Names: XL 880, EXEL 2880, Foretinib
Chemical Name: N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for GSK 1363089

GSK 1363089 is a potent inhibitor of MET, VEGFR2, Ron and AXL (IC50 values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFRα and PDGFRβ. Inhibits migration and invasion of B16F10 melanoma cells in vitro. Suppresses B16F10 tumor growth and metastasis in mice. Orally available.

Technical Data for GSK 1363089

M. Wt 632.65
Formula C34H34F2N4O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 849217-64-7
PubChem ID 42642645

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 1363089

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 63.26 100
ethanol 63.26 100

Preparing Stock Solutions for GSK 1363089

The following data is based on the product molecular weight 632.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.58 mL 7.9 mL 15.81 mL
5 mM 0.32 mL 1.58 mL 3.16 mL
10 mM 0.16 mL 0.79 mL 1.58 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for GSK 1363089

References are publications that support the biological activity of the product.

Myers et al (2016) AXL inhibitors in cancer: A medicinal chemistry perspective. J.Med.Chem. 59 3593 PMID: 26555154

Faria et al (2015) Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma. Cancer Res. 75 134 PMID: 25391241

Qian et al (2009) Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 69 8009 PMID: 19808973

If you know of a relevant reference for GSK 1363089, please let us know.

View Related Products by Product Action

View all MET Receptor Inhibitors

Keywords: GSK 1363089, GSK 1363089 supplier, GSK1363089, potent, inhibitors, inhibits, HGF, VEGFR2, AXL, tyrosine, kinases, orally, available, XL880, EXEL2880, XL, 880, EXEL, 2880, Foretinib, MET, Receptors, VEGFR, FLT3, PDGFR, 6056, Tocris Bioscience

Citations for GSK 1363089

Citations are publications that use Tocris products.

Currently there are no citations for GSK 1363089. Do you know of a great paper that uses GSK 1363089 from Tocris? Please let us know.

Reviews for GSK 1363089

There are currently no reviews for this product. Be the first to review GSK 1363089 and earn rewards!

Have you used GSK 1363089?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases