MET Receptors

The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4368 Crizotinib
Potent c-MET/ALK inhibitor
6056 GSK 1363089
Potent inhibitor of MET, VEGFR2, Ron and AXL
1683 K 252a
Receptor tyrosine kinase inhibitor, inhibits MET
5369 Norleual
Highly potent HGF/c-MET inhibitor; also AT4 antagonist
4239 PF 04217903 mesylate
Highly selective MET inhibitor
2693 PHA 665752
Potent and selective MET inhibitor
5356 SGX 523
Selective and potent c-MET kinase inhibitor
4101 SU 11274
Selective inhibitor of MET kinase activity
3037 SU 5416
MET inhibitor. Also inhibits KIT, RET, VEGFR and FLT3
5422 XL 184
Potent c-MET inhibitor; also inhibits other RTKs

The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for the MET receptor is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells.

In the adult, MET receptor expression is limited to stem and progenitor cells and is necessary for wound healing and hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are essential for invasive growth and mediate epithelial-mesenchymal transition (EMT).

Aberrant activation of the HGF/MET pathway leads to a variety of cancers. MET receptor mutations are associated with poor prognosis as they can trigger tumor growth, angiogenesis and metastasis.

Literature for MET Receptors

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

MET Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human MET NM_000245 P08581
Mouse Met NM_008591 P16056
Rat Met NM_031517 P97523