GSK 1059615

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Cat.No. 4026 - GSK 1059615 | C18H11N3O2S | CAS No. 958852-01-2
Description: Potent PI 3-kinase inhibitor
Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 333.36
Formula C18H11N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 958852-01-2
PubChem ID 23582824
InChI Key QDITZBLZQQZVEE-YBEGLDIGSA-N
Smiles O=C(/C(S4)=C/C1=CC=C2C(C(C3=CC=NC=C3)=CC=N2)=C1)NC4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.33 10

Preparing Stock Solutions

The following data is based on the product molecular weight 333.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30 mL 149.99 mL 299.98 mL
0.5 mM 6 mL 30 mL 60 mL
1 mM 3 mL 15 mL 30 mL
5 mM 0.6 mL 3 mL 6 mL

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References

References are publications that support the biological activity of the product.

Saadia et al (2009) Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin.Cancer Res. 15 3029 PMID: 19383818

Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39


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Citations for GSK 1059615

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