GSK 1059615

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Cat.No. 4026 - GSK 1059615 | C18H11N3O2S | CAS No. 958852-01-2
Description: Potent PI 3-kinase inhibitor
Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for GSK 1059615

GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GSK 1059615

M. Wt 333.36
Formula C18H11N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 958852-01-2
PubChem ID 23582824
Smiles O=C(/C(S4)=C/C1=CC=C2C(C(C3=CC=NC=C3)=CC=N2)=C1)NC4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 1059615

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.33 10

Preparing Stock Solutions for GSK 1059615

The following data is based on the product molecular weight 333.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30 mL 149.99 mL 299.98 mL
0.5 mM 6 mL 30 mL 60 mL
1 mM 3 mL 15 mL 30 mL
5 mM 0.6 mL 3 mL 6 mL

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References for GSK 1059615

References are publications that support the biological activity of the product.

Saadia et al (2009) Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin.Cancer Res. 15 3029 PMID: 19383818

Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39

If you know of a relevant reference for GSK 1059615, please let us know.

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Citations for GSK 1059615

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