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GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.
Sold for research purposes under agreement from GlaxoSmithKline
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Saadia et al (2009) Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin.Cancer Res. 15 3029 PMID: 19383818
Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39
Keywords: GSK 1059615, GSK 1059615 supplier, Potent, inhibitors, inhibits, PI3Kα, PI3Ka, PI3Kalpha, PI3Kinasealpha, GSK1059615, PI3-kinases, phosphoinositide, 3, kinases, PI, 3-Kinase, 4026, Tocris Bioscience
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