GSA 10

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Cat.No. 4918 - GSA 10 | C26H30N2O5 | CAS No. 300833-95-8
Description: Smo receptor agonist
Chemical Name: 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Smoothened (Smo) receptor agonist (EC50 = 1.2 μM). Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Technical Data

M. Wt 450.53
Formula C26H30N2O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 300833-95-8
PubChem ID 54683103
InChI Key MDLUYYGRCGDKGL-UHFFFAOYSA-N
Smiles OC(C1=CC=CC=C1N2CCCCCC)=C(C(NC3=CC=C(C(OCCC)=O)C=C3)=O)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.25 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 450.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 44.39 mL 221.96 mL 443.92 mL
0.25 mM 8.88 mL 44.39 mL 88.78 mL
0.5 mM 4.44 mL 22.2 mL 44.39 mL
2.5 mM 0.89 mL 4.44 mL 8.88 mL

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References

References are publications that support the biological activity of the product.

Gorojankina et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 83 1020 PMID: 23448715


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Citations for GSA 10

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Literature in this Area

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