GSA 10

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Cat.No. 4918 - GSA 10 | C26H30N2O5 | CAS No. 300833-95-8
Description: Smo receptor agonist
Chemical Name: 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for GSA 10

GSA 10 is a smoothened (Smo) receptor agonist (EC50 = 1.2 μM). Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Displays anti-adipogenic effects in vitro, mediated by a non-canonical Hedgehog signaling pathway. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Technical Data for GSA 10

M. Wt 450.53
Formula C26H30N2O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 300833-95-8
PubChem ID 54683103

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSA 10

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.25 5 with gentle warming

Preparing Stock Solutions for GSA 10

The following data is based on the product molecular weight 450.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 44.39 mL 221.96 mL 443.92 mL
0.25 mM 8.88 mL 44.39 mL 88.78 mL
0.5 mM 4.44 mL 22.2 mL 44.39 mL
2.5 mM 0.89 mL 4.44 mL 8.88 mL

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References for GSA 10

References are publications that support the biological activity of the product.

Gorojankina et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 83 1020 PMID: 23448715

Fleury et al (2016) Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci.Rep. 24 23479 PMID: 27010359

If you know of a relevant reference for GSA 10, please let us know.

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Citations for GSA 10

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