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Smoothened (Smo) receptor agonist (EC50 = 1.2 μM). Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Displays anti-adipogenic effects in vitro, mediated by a non-canonical Hedgehog signaling pathway. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.25||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 450.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||44.39 mL||221.96 mL||443.92 mL|
|0.25 mM||8.88 mL||44.39 mL||88.78 mL|
|0.5 mM||4.44 mL||22.2 mL||44.39 mL|
|2.5 mM||0.89 mL||4.44 mL||8.88 mL|
References are publications that support the biological activity of the product.
Gorojankina et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 83 1020 PMID: 23448715
Fleury et al (2016) Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci.Rep. 24 23479 PMID: 27010359
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Keywords: GSA 10, GSA 10 supplier, GSA10, Smoothened, Smo, receptors, agonists, differentiation, multipotent, mesenchymal, progenitor, cells, osteoblasts, osteogenic, Receptors, Mesenchymal, Stem, Cells, Osteogenic, 4918, Tocris Bioscience
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