GRL 0617

Pricing Availability   Qty
Description: Coronavirus PLpro inhibitor
Chemical Name: 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
Purity: ≥98% (HPLC)

Biological Activity for GRL 0617

GRL 0617 is a coronavirus papain-like protease (Plpro) inhibitor (IC50 values are 0.6 and 0.8 μM for SARS-COV and SARS-CoV-2 PLpro, respectively). Inhibits deubiquitination activity of SARS-CoV PLpro. Displays no inhibition of human deubiquitinating enzymes. Improves cell viability following SARS-CoV infection. Inhibits SARS-CoV-2 viral replication and induces antiviral immune signaling pathways following SARS-CoV-2 infection in CaCo-2 cells.

Compound Libraries for GRL 0617

GRL 0617 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GRL 0617

M. Wt 304.39
Formula C20H20N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1093070-16-6
PubChem ID 24941262
Smiles C[C@H](C1=CC=CC2=C1C=CC=C2)NC(C3=C(C=CC(N)=C3)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GRL 0617

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.44 100
ethanol 30.44 100

Preparing Stock Solutions for GRL 0617

The following data is based on the product molecular weight 304.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.43 mL 32.85 mL
5 mM 0.66 mL 3.29 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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References for GRL 0617

References are publications that support the biological activity of the product.

Ratia et al (2008) A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc.Natl.Acad.Sci.USA. 105 16119 PMID: 18852458

Freitas et al (2020) Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-Like protease. ACS Infect.Dis. 6 2099 PMID: 32428392

Shin et al (2020) Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 587 657 PMID: 32726803

If you know of a relevant reference for GRL 0617, please let us know.

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Citations for GRL 0617

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